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Protein structure
AMH
Anti-Mullerian hormoneMIS
This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate N- and C-terminal cleavage products that homodimerize and associate to form a biologically active noncovalent complex. This complex binds to the anti-Mullerian hormone receptor type 2 and causes the regression of Mullerian ducts in the male embryo that would otherwise differentiate into the uterus and fallopian tubes. This protein also plays a role in Leydig cell differentiation and function and follicular development in adult females. Mutations in this gene result in persistent Mullerian duct syndrome. [provided by RefSeq, Jul 2016]
Top validated antibodies |
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| Proteintech Group |  14461-1-AP |
8 references | Polyclonal |
WB
EL
IHC
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| LSBio | LS-C370759 |
Polyclonal |
WB
EL
IHC
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| antibodies-online | ABIN2843140 |
1 references | Polyclonal |
WB
IHC
FC
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| GeneTex | GTX129593 |
1 references | Polyclonal |
WB
ICC
IHC
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| NSJ Bioreagents | F52011 |
Polyclonal |
WB
EL
IHC
FC
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