PFKP

The PFKP gene encodes the platelet isoform of phosphofructokinase (PFK) (ATP:D-fructose-6-phosphate-1-phosphotransferase, EC 2.7.1.11). PFK catalyzes the irreversible conversion of fructose-6-phosphate to fructose-1,6-bisphosphate and is a key regulatory enzyme in glycolysis. The PFKP gene, which maps to chromosome 10p, is also expressed in fibroblasts. See also the muscle (PFKM; MIM 610681) and liver (PFKL; MIM 171860) isoforms of phosphofructokinase, which map to chromosomes 12q13 and 21q22, respectively. Vora (1981) [PubMed 6451249] determined that full tetrameric phophofructokinase enzyme expressed in platelets can be composed of subunits P4, P3L, and P2L2. [supplied by OMIM, Mar 2008]

Description

phosphofructokinase, platelet

Protein family

Enzymes, Mapped to UniProt SWISS-PROT, Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins, Protein evidence (Ezkurdia et al 2014), Protein evidence (Kim et al 2014)

Chromosome

10:p15.2 (3066333 - 3137712)

Ensembl ID

ENSG00000067057  (ver. 84.38)

Orthologs

Mouse Pfkp: ENSMUSG00000021196

UniProt

Q01813

neXtProt

NX_Q01813

Human splice variants
Mouse splice variants