ADAM18

This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biologic processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The encoded preproprotein is proteolytically processed to generate the mature sperm surface protein. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Feb 2016]

Description

ADAM metallopeptidase domain 18

Tissue specificity

Tissue enriched (testis)

Predicted location

Intracellular, Membrane

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Predicted membrane proteins
Protein evidence (Kim et al 2014)

Chromosome

8 (39584489 - 39730065)

Ensembl ID

ENSG00000168619  (ver. 103.38)

Orthologs

Mouse Adam18: ENSMUSG00000031552

UniProt

Q9Y3Q7

neXtProt

NX_Q9Y3Q7

Human splice variants
Mouse splice variants

Protein structure