PTGIS

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. However, this protein is considered a member of the cytochrome P450 superfamily on the basis of sequence similarity rather than functional similarity. This endoplasmic reticulum membrane protein catalyzes the conversion of prostglandin H2 to prostacyclin (prostaglandin I2), a potent vasodilator and inhibitor of platelet aggregation. An imbalance of prostacyclin and its physiological antagonist thromboxane A2 contribute to the development of myocardial infarction, stroke, and atherosclerosis. [provided by RefSeq, Jul 2008]

Description

Prostaglandin I2 synthase

Tissue specificity

Tissue enhanced (endometrium , fallopian tube, urinary bladder)

Subcell location

Endoplasmic reticulum

Predicted location

Membrane

Protein family

Disease related genes
Enzymes
FDA approved drug targets
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Metabolic proteins
Plasma proteins
Predicted membrane proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

20 (49503874 - 49568137)

Ensembl ID

ENSG00000124212  (ver. 103.38)

Orthologs

Mouse Ptgis: ENSMUSG00000017969

UniProt

Q16647

neXtProt

NX_Q16647

Human splice variants
Mouse splice variants

Protein structure