Tissue expression
Cell line expression
Protein structure
CKMT1B
Creatine kinase, mitochondrial 1BCKMT, CKMT1, UMTCK
Mitochondrial creatine (MtCK) kinase is responsible for the transfer of high energy phosphate from mitochondria to the cytosolic carrier, creatine. It belongs to the creatine kinase isoenzyme family. It exists as two isoenzymes, sarcomeric MtCK and ubiquitous MtCK, encoded by separate genes. Mitochondrial creatine kinase occurs in two different oligomeric forms: dimers and octamers, in contrast to the exclusively dimeric cytosolic creatine kinase isoenzymes. Many malignant cancers with poor prognosis have shown overexpression of ubiquitous mitochondrial creatine kinase; this may be related to high energy turnover and failure to eliminate cancer cells via apoptosis. Ubiquitous mitochondrial creatine kinase has 80% homology with the coding exons of sarcomeric mitochondrial creatine kinase. Two genes located near each other on chromosome 15 have been identified which encode identical mitochondrial creatine kinase proteins. [provided by RefSeq, Jul 2008]
Top validated antibodies |
|||||
Invitrogen Antibodies | PA5-96224 | Polyclonal |
WB
ICC
IP
IHC |
||
St John's Laboratory | STJ23148 | Polyclonal |
WB
ICC
IP
IHC
ChIP
|
||
OriGene | AM50081PU-N | Monoclonal |
WB
EL
ICC
FC |
||
LSBio | LS-C831043 | Polyclonal |
WB
EL
IHC
|
||
FineTest Biotech | FNab01727 | Polyclonal |
WB
EL
IP
IHC |
All Antibodies
Filters
Enhanced validation
Supportive data in Antibodypedia
Data presented on provider website
Data in Antibodypedia (inconclusive)
Recommended by provider
Supportive data in Antibodypedia
Data presented on provider website
Data in Antibodypedia (inconclusive)
Recommended by provider