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ABAT
4-aminobutyrate aminotransferaseGABA-T, GABAT
4-aminobutyrate aminotransferase (ABAT) is responsible for catabolism of gamma-aminobutyric acid (GABA), an important, mostly inhibitory neurotransmitter in the central nervous system, into succinic semialdehyde. The active enzyme is a homodimer of 50-kD subunits complexed to pyridoxal-5-phosphate. The protein sequence is over 95% similar to the pig protein. GABA is estimated to be present in nearly one-third of human synapses. ABAT in liver and brain is controlled by 2 codominant alleles with a frequency in a Caucasian population of 0.56 and 0.44. The ABAT deficiency phenotype includes psychomotor retardation, hypotonia, hyperreflexia, lethargy, refractory seizures, and EEG abnormalities. Multiple alternatively spliced transcript variants encoding the same protein isoform have been found for this gene. [provided by RefSeq, Jul 2008]
Top validated antibodies |
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| Proteintech Group |  11349-1-AP |
6 references | Polyclonal |
WB
EL
IP
IHC
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| LSBio | LS-C375103 |
Polyclonal |
WB
EL
IHC
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| Invitrogen Antibodies | UM800070 |
Monoclonal |
WB
ICC
IHC
ChIP
OA
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| OriGene | UM800070 |
Monoclonal |
WB
ICC
IHC
OA
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| NovoPro Bioscience Inc. | 107679 |
Polyclonal |
WB
EL
IP
IHC
|
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