Tissue expression
Cell line expression
Protein structure
MSH3
MutS homolog 3DUP, MRP1
The protein encoded by this gene forms a heterodimer with MSH2 to form MutS beta, part of the post-replicative DNA mismatch repair system. MutS beta initiates mismatch repair by binding to a mismatch and then forming a complex with MutL alpha heterodimer. This gene contains a polymorphic 9 bp tandem repeat sequence in the first exon. The repeat is present 6 times in the reference genome sequence and 3-7 repeats have been reported. Defects in this gene are a cause of susceptibility to endometrial cancer. [provided by RefSeq, Mar 2011]
Top validated antibodies |
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| Proteintech Group | 6 references | Polyclonal |
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| LSBio | Polyclonal |
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| Novus Biologicals | 1 references | Polyclonal |
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| Invitrogen Antibodies | 1 references | Polyclonal |
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| antibodies-online | 4 references | Monoclonal |
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