PCDH10

This gene belongs to the protocadherin gene family, a subfamily of the cadherin superfamily. This family member contains 6 extracellular cadherin domains, a transmembrane domain and a cytoplasmic tail differing from those of the classical cadherins. The encoded protein is a cadherin-related neuronal receptor thought to function in the establishment of specific cell-cell connections in the brain. This gene plays a role in inhibiting cancer cell motility and cell migration. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2015]

Description

Protocadherin 10

Tissue specificity

Tissue enhanced (brain, placenta, seminal vesicle)

Subcell location

Nucleoplasm, Golgi apparatus, Vesicles

Predicted location

Membrane

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted membrane proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

4:q28.3 (133149294 - 133208606)

Ensembl ID

ENSG00000138650  (ver. 103.38)

Orthologs

Mouse Pcdh10: ENSMUSG00000049100

UniProt

Q9P2E7

neXtProt

NX_Q9P2E7

Human splice variants
Mouse splice variants