PTRH2

gene product
BIT1, CFAP37, CGI-147, PTH2
The protein encoded by this gene is a mitochondrial protein with two putative domains, an N-terminal mitochondrial localization sequence, and a UPF0099 domain. In vitro assays suggest that this protein possesses peptidyl-tRNA hydrolase activity, to release the peptidyl moiety from tRNA, thereby preventing the accumulation of dissociated peptidyl-tRNA that could reduce the efficiency of translation. This protein also plays a role regulating cell survival and death. It promotes survival as part of an integrin-signaling pathway for cells attached to the extracellular matrix (ECM), but also promotes apoptosis in cells that have lost their attachment to the ECM, a process called anoikos. After loss of cell attachment to the ECM, this protein is phosphorylated, is released from the mitochondria into the cytosol, and promotes caspase-independent apoptosis through interactions with transcriptional regulators. This gene has been implicated in the development and progression of tumors, and mutations in this gene have been associated with an infantile multisystem neurologic, endocrine, and pancreatic disease (INMEPD) characterized by intellectual disability, postnatal microcephaly, progressive cerebellar atrophy, hearing impairment, polyneuropathy, failure to thrive, and organ fibrosis with exocrine pancreas insufficiency (PMID: 25574476). Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2015]
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Novus Biologicals
22 antibodies
Atlas Antibodies
1 antibody
GeneTex
4 antibodies
antibodies-online
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LifeSpan BioSciences, Inc.
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Abnova Corporation
7 antibodies
OriGene
6 antibodies
NovoPro Bioscience Inc.
1 antibody
Biorbyt
10 antibodies
Invitrogen Antibodies
3 antibodies
Rockland Immunochemicals, Inc.
2 antibodies
Proteintech Group
1 antibody
Acris Antibodies GmbH
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ProSci
3 antibodies
Abgent
3 antibodies
St John's Laboratory
1 antibody
Aviva Systems Biology
4 antibodies
Bioworld Technology, Inc
1 antibody
Affinity Biosciences
1 antibody
Bethyl Laboratories
1 antibody
MyBioSource
6 antibodies
RabMAbs
2 antibodies
Abbiotec
2 antibodies
Boster Biological Technology
1 antibody
Cell Signaling Technology, Inc
1 antibody
United States Biological
69 antibodies
Creative Biolabs
3 antibodies
Sigma-Aldrich
3 antibodies
RayBiotech, Inc.
1 antibody
Creative Diagnostics
3 antibodies
GenWay
1 antibody