PTPRF

gene product
LAR
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem intracytoplasmic catalytic domains, and thus represents a receptor-type PTP. The extracellular region contains three Ig-like domains, and nine non-Ig like domains similar to that of neural-cell adhesion molecule. This PTP was shown to function in the regulation of epithelial cell-cell contacts at adherents junctions, as well as in the control of beta-catenin signaling. An increased expression level of this protein was found in the insulin-responsive tissue of obese, insulin-resistant individuals, and may contribute to the pathogenesis of insulin resistance. Two alternatively spliced transcript variants of this gene, which encode distinct proteins, have been reported. [provided by RefSeq, Jul 2008]
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AntibodyRefsTypeWBELICCIPIHCFC
antibodies-online
56 antibodies
Novus Biologicals
20 antibodies
LifeSpan BioSciences, Inc.
30 antibodies
Invitrogen Antibodies
2 antibodies
NSJ Bioreagents
1 antibody
Biorbyt
22 antibodies
Abbkine Scientific Co.Ltd.
1 antibody
Boster Biological Technology
1 antibody
Cell Signaling Technology, Inc
1 antibody
UC Davis/NIH NeuroMab Facility
4 antibodies
R&D Systems
2 antibodies
MyBioSource
3 antibodies
Acris Antibodies GmbH
2 antibodies
Abnova Corporation
3 antibodies
OriGene
2 antibodies
Atlas Antibodies
1 antibody
St John's Laboratory
2 antibodies
GeneTex
1 antibody
ProSci
1 antibody
Rockland Immunochemicals, Inc.
18 antibodies
Creative Diagnostics
3 antibodies
EMD Millipore
3 antibodies
Sigma-Aldrich
2 antibodies
RayBiotech, Inc.
1 antibody