PTPRF

gene product
LAR
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem intracytoplasmic catalytic domains, and thus represents a receptor-type PTP. The extracellular region contains three Ig-like domains, and nine non-Ig like domains similar to that of neural-cell adhesion molecule. This PTP was shown to function in the regulation of epithelial cell-cell contacts at adherents junctions, as well as in the control of beta-catenin signaling. An increased expression level of this protein was found in the insulin-responsive tissue of obese, insulin-resistant individuals, and may contribute to the pathogenesis of insulin resistance. Two alternatively spliced transcript variants of this gene, which encode distinct proteins, have been reported. [provided by RefSeq, Jul 2008]
More gene data

Featured antibodies

Antibodies

 

Filters

Application

Antibodypedia Validation Initiative

Validation method

Reference

Provider

Host

Reactivity

Antibody type

Conjugate

Antibody

  or   Clear
Enhanced validation
Enhanced validation
Supportive data in Antibodypedia
Data presented on provider website
Data in Antibodypedia (inconclusive)
Validated within AVI
Eligible for validation within AVI
272 antibodies from 26 providers.

Antibody properties

General

Applications

or Cancel
Antibody
antibodies-online
116 antibodies
Cell Signaling Technology, Inc
4 antibodies
Novus Biologicals
22 antibodies
LifeSpan BioSciences, Inc.
39 antibodies
Invitrogen Antibodies
2 antibodies
Atlas Antibodies
1 antibody
NSJ Bioreagents
1 antibody
Antibodies Incorporated
2 antibodies
Abbkine Scientific Co.Ltd.
1 antibody
Boster Biological Technology
1 antibody
UC Davis/NIH NeuroMab Facility
4 antibodies
Biorbyt
31 antibodies
R&D Systems
2 antibodies
MyBioSource
3 antibodies
Acris Antibodies GmbH
2 antibodies
Abnova Corporation
3 antibodies
OriGene
2 antibodies
St John's Laboratory
2 antibodies
GeneTex
1 antibody
ProSci
1 antibody
Rockland Immunochemicals, Inc.
18 antibodies
Creative Diagnostics
3 antibodies
EMD Millipore
3 antibodies
Creative Biolabs
5 antibodies
Sigma-Aldrich
2 antibodies
RayBiotech, Inc.
1 antibody