Tissue expressionAmygdalaBasal gangliaCerebellumCerebral cortexChoroid plexusHippocampal formationHypothalamusMedulla oblongataMidbrainOlfactory bulbPonsSpinal cordThalamusWhite matterRetinaAdrenal glandParathyroid glandPituitary glandThyroid glandLungEsophagusSalivary glandTongueColonDuodenumRectumSmall intestineStomachGallbladderLiverPancreasKidneyUrinary bladderEpididymisProstateSeminal vesicleTestisBreastCervixEndometriumFallopian tubeOvaryPlacentaVaginaHeart muscleSkeletal muscleSmooth muscleAdipose tissueSkinAppendixBone marrowLymph nodeSpleenThymusTonsil020406080100120
Cell line expressionAF22GAMGSH-SY5YU-138 MGU-251 MGU-87 MGHTCEpiHTERT-RPE1OE19CACO-2Hep G2CAPAN-2HEK 293NTERA-2RPTEC TERT1RT4PC-3SuSaA-431HaCaTSK-MEL-30WM-115A549HBEC3-KTSCLC-21HAN3-CABEWOEFO-21HeLaHTERT-HME1MCF7SiHaSK-BR-3T-47dHUVEC TERT2TIMEHSkMCASC diffASC TERT1BJBJ hTERT+BJ hTERT+ SV40 Large T+BJ hTERT+ SV40 Large T+ RasG12VFHDF/TERT166HBF TERT88HHSteCLHCN-M2RH-30U-2 OSU-2197DaudiHDLM-2HTEC/SVTERT24-BJURKATKarpas-707MOLT-4REHRPMI-8226U-266/70U-266/84U-698HAP1HELHL-60HMC-1K-562NB-4THP-1U-937050100150200250300350
Protein structure

PTPRF

Protein tyrosine phosphatase receptor type F
LAR 
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem intracytoplasmic catalytic domains, and thus represents a receptor-type PTP. The extracellular region contains three Ig-like domains, and nine non-Ig like domains similar to that of neural-cell adhesion molecule. This PTP was shown to function in the regulation of epithelial cell-cell contacts at adherents junctions, as well as in the control of beta-catenin signaling. An increased expression level of this protein was found in the insulin-responsive tissue of obese, insulin-resistant individuals, and may contribute to the pathogenesis of insulin resistance. Two alternatively spliced transcript variants of this gene, which encode distinct proteins, have been reported. [provided by RefSeq, Jul 2008]
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                        337 antibodies from 35 providers.

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                        Antibody
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                        WB
                        EL
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                        FC
                        Biorbyt
                        17 antibodies
                        Atlas Antibodies
                        1 antibody
                        antibodies-online
                        116 antibodies
                        Invitrogen Antibodies
                        16 antibodies
                        Abbexa
                        19 antibodies
                        Cell Signaling Technology, Inc
                        4 antibodies
                        Cusabio Biotech Co., Ltd
                        4 antibodies
                        NSJ Bioreagents
                        1 antibody
                        Novus Biologicals
                        22 antibodies
                        Antibodies Incorporated / NeuroMab
                        2 antibodies
                        Boster Biological Technology
                        2 antibodies
                        OriGene
                        6 antibodies
                        Antibodies.com
                        5 antibodies
                        Abbkine Scientific Co.Ltd.
                        1 antibody
                        FineTest Biotech
                        1 antibody
                        HUABIO Research
                        1 antibody
                        QED Bioscience
                        1 antibody
                        UC Davis/NIH NeuroMab Facility
                        4 antibodies
                        R&D Systems
                        2 antibodies
                        MyBioSource
                        3 antibodies
                        Acris Antibodies GmbH
                        2 antibodies
                        St John's Laboratory
                        2 antibodies
                        Abnova Corporation
                        3 antibodies
                        GeneTex
                        1 antibody
                        ProSci
                        1 antibody
                        Proteintech Group
                        1 antibody
                        Rockland Immunochemicals, Inc.
                        17 antibodies
                        EMD Millipore
                        3 antibodies
                        MilliporeSigma / Merck KGaA
                        4 antibodies
                        Creative Biolabs
                        11 antibodies
                        Absolute Antibody
                        2 antibodies
                        RayBiotech, Inc.
                        1 antibody
                        Creative Diagnostics
                        5 antibodies