JARID2

This gene encodes a Jumonji- and AT-rich interaction domain (ARID)-domain-containing protein. The encoded protein is a DNA-binding protein that functions as a transcriptional repressor. This protein interacts with the Polycomb repressive complex 2 (PRC2) which plays an essential role in regulating gene expression during embryonic development. This protein facilitates the recruitment of the PRC2 complex to target genes. Alternate splicing results in multiple transcript variants. Mutations in this gene are associated with chronic myeloid malignancies. [provided by RefSeq, May 2012]

Description

Jumonji and AT-rich interaction domain containing 2

Tissue specificity

Tissue enhanced (bone marrow)

Subcell location

Nucleoplasm, Mitochondria

Predicted location

Intracellular

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Plasma proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)
Transcription factors

Chromosome

6 (15246069 - 15522042)

Ensembl ID

ENSG00000008083  (ver. 103.38)

Orthologs

Mouse Jarid2: ENSMUSG00000038518

UniProt

Q92833

neXtProt

NX_Q92833

Human splice variants
Mouse splice variants

Protein structure