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RUNX1T1
RUNX1 partner transcriptional co-repressor 1AML1T1, CBFA2T1, CDR, ETO, MTG8, ZMYND2
This gene encodes a member of the myeloid translocation gene family which interact with DNA-bound transcription factors and recruit a range of corepressors to facilitate transcriptional repression. The t(8;21)(q22;q22) translocation is one of the most frequent karyotypic abnormalities in acute myeloid leukemia. The translocation produces a chimeric gene made up of the 5'-region of the runt-related transcription factor 1 gene fused to the 3'-region of this gene. The chimeric protein is thought to associate with the nuclear corepressor/histone deacetylase complex to block hematopoietic differentiation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2010]
Top validated antibodies |
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| NSJ Bioreagents |  RQ4332 |
Polyclonal |
WB
EL
ICC
IP
IHC
FC
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| Proteintech Group | 15494-1-AP |
3 references | Polyclonal |
WB
EL
IP
IHC
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| Invitrogen Antibodies | PA5-79943 |
Polyclonal |
WB
EL
ICC
IHC
FC
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| Boster Biological Technology | A01792-1 |
Polyclonal |
WB
EL
ICC
IHC
FC
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| LSBio | LS-C196824 |
Monoclonal |
WB
EL
ICC
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