TMED10

This gene is a member of the EMP24/GP25L/p24 family and encodes a protein with a GOLD domain. This type I membrane protein is localized to the plasma membrane and golgi cisternae and is involved in vesicular protein trafficking. The protein is also a member of a heteromeric secretase complex and regulates the complex's gamma-secretase activity without affecting its epsilon-secretase activity. Mutations in this gene have been associated with early-onset familial Alzheimer's disease. This gene has a pseudogene on chromosome 8. [provided by RefSeq, Jul 2008]

Description

Transmembrane p24 trafficking protein 10

Tissue specificity

Low tissue specificity

Subcell location

Golgi apparatus

Predicted location

Membrane

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted membrane proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)
Transporters

Chromosome

14:q24.3 (75131469 - 75176612)

Ensembl ID

ENSG00000170348  (ver. 103.38)

Orthologs

Mouse Tmed10: ENSMUSG00000021248

UniProt

P49755

neXtProt

NX_P49755

Human splice variants
Mouse splice variants