UBD

This gene encodes a protein which contains two ubiquitin-like domains and appears to have similar function to ubiquitin. Through covalent attachment, the encoded protein targets other proteins for 26S proteasome degradation. This protein has been implicated to function in many cellular processes, including caspase-dependent apoptosis, formation of aggresomes, mitotic regulation, and dendritic cell maturation. Upregulation of this gene may promote inflammation in chronic kidney disease and has been observed in many cancer types. [provided by RefSeq, Aug 2017]

Description

Ubiquitin D

Tissue specificity

Tissue enriched (lymphoid tissue)

Subcell location

Nucleoplasm, Nucleoli fibrillar center

Predicted location

Intracellular

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins

Chromosome

6 (29555515 - 29559732)

Ensembl ID

ENSG00000213886  (ver. 103.38)

Orthologs

Mouse Ubd: ENSMUSG00000035186

UniProt

O15205

neXtProt

NX_O15205

Human splice variants
Mouse splice variants

Protein structure