Tissue expression
Cell line expression
Protein structure

CACNA1A

Calcium voltage-gated channel subunit alpha1 A
APCA, CACNL1A4, Cav2.1, EA2, FHM, HPCA, MHP, MHP1, SCA6 
Voltage-dependent calcium channels mediate the entry of calcium ions into excitable cells, and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, and gene expression. Calcium channels are multisubunit complexes composed of alpha-1, beta, alpha-2/delta, and gamma subunits. The channel activity is directed by the pore-forming alpha-1 subunit, whereas, the others act as auxiliary subunits regulating this activity. The distinctive properties of the calcium channel types are related primarily to the expression of a variety of alpha-1 isoforms, alpha-1A, B, C, D, E, and S. This gene encodes the alpha-1A subunit, which is predominantly expressed in neuronal tissue. Mutations in this gene are associated with 2 neurologic disorders, familial hemiplegic migraine and episodic ataxia 2. This gene also exhibits polymorphic variation due to (CAG)n-repeats. Multiple transcript variants encoding different isoforms have been found for this gene. In one set of transcript variants, the (CAG)n-repeats occur in the 3' UTR, and are not associated with any disease. But in another set of variants, an insertion extends the coding region to include the (CAG)n-repeats which encode a polyglutamine tract. Expansion of the (CAG)n-repeats from the normal 4-18 to 21-33 in the coding region is associated with spinocerebellar ataxia 6. [provided by RefSeq, Jul 2016]
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112 antibodies from 22 providers.

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AntibodyRefsTypeWBELICCIPIHCFC
antibodies-online
29 antibodies
Invitrogen Antibodies
13 antibodies
GeneTex
1 antibody
Biorbyt
16 antibodies
Cusabio Biotech Co., Ltd
5 antibodies
Atlas Antibodies
1 antibody
NSJ Bioreagents
1 antibody
NovoPro Bioscience Inc.
1 antibody
Proteintech Group
1 antibody
Creative Biolabs
5 antibodies
Novus Biologicals
1 antibody
OriGene
1 antibody
Abbkine Scientific Co.Ltd.
1 antibody
EMD Millipore
2 antibodies
Creative Diagnostics
2 antibodies
Abbexa
2 antibodies
St John's Laboratory
1 antibody
MyBioSource
2 antibodies
Leading Biology
1 antibody
MilliporeSigma / Merck KGaA
1 antibody