FNBP4

This gene encodes a protein containing two tryptophan-rich WW domains that binds the proline-rich formin homology 1 domains of formin family proteins, suggesting a role in the regulation of cytoskeletal dynamics during cell division and migration. It also binds intersectin family proteins suggesting a role in the maintenance of membrane curvature at sites of nascent vesicle formation. Naturally occurring mutations in this gene are associated with Waardenburg anophthalmia syndrome. [provided by RefSeq, Apr 2017]

Description

Formin binding protein 4

Tissue specificity

Low tissue specificity

Subcell location

Nuclear speckles

Predicted location

Intracellular

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

11:p11.2 (47716494 - 47767443)

Ensembl ID

ENSG00000109920  (ver. 103.38)

Orthologs

Mouse Fnbp4: ENSMUSG00000008200

UniProt

Q8N3X1

neXtProt

NX_Q8N3X1

Human splice variants
Mouse splice variants