PSTPIP1

gene product
CD2BP1, CD2BP1L, CD2BP1S, H-PIP, PAPAS, PSTPIP
This gene encodes a cytoskeletal protein that is highly expressed in hemopoietic tissues. This protein functions via its interaction with several different proteins involved in cytoskeletal organization and inflammatory processes. It binds to the cytoplasmic tail of CD2, an effector of T cell activation and adhesion, downregulating CD2-triggered adhesion. It binds PEST-type protein tyrosine phosphatases (PTP) and directs them to c-Abl kinase to mediate c-Abl dephosphorylation, thereby, regulating c-Abl activity. It also interacts with pyrin, which is found in association with the cytoskeleton in myeloid/monocytic cells and modulates immunoregulatory functions. Mutations in this gene are associated with PAPA (pyogenic sterile arthritis, pyoderma gangrenosum, and acne) syndrome. It is hypothesized that the disease-causing mutations compromise physiologic signaling necessary for the maintenance of a proper inflammatory response. [provided by RefSeq, Mar 2016]
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Novus Biologicals
3 antibodies
Atlas Antibodies
1 antibody
NovoPro Bioscience Inc.
2 antibodies
Proteintech Group
1 antibody
antibodies-online
64 antibodies
LifeSpan BioSciences, Inc.
28 antibodies
Biorbyt
9 antibodies
Abnova Corporation
2 antibodies
Abgent
1 antibody
Invitrogen Antibodies
3 antibodies
St John's Laboratory
2 antibodies
GeneTex
2 antibodies
Abbexa
1 antibody
Aviva Systems Biology
3 antibodies
OriGene
2 antibodies
Acris Antibodies GmbH
3 antibodies
ProSci
1 antibody
MyBioSource
4 antibodies
United States Biological
25 antibodies
Creative Diagnostics
3 antibodies
Creative Biolabs
2 antibodies
Sigma-Aldrich
2 antibodies