TIAM2

This gene encodes a guanine nucleotide exchange factor. A highly similar mouse protein specifically activates ras-related C3 botulinum substrate 1, converting this Rho-like guanosine triphosphatase (GTPase) from a guanosine diphosphate-bound inactive state to a guanosine triphosphate-bound active state. The encoded protein may play a role in neural cell development. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]

Description

TIAM Rac1 associated GEF 2

Tissue specificity

Tissue enhanced (brain, testis)

Subcell location

Nucleoplasm, Nucleoli fibrillar center, Cytosol

Predicted location

Intracellular

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Metabolic proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)

Chromosome

6 (154832697 - 155257723)

Ensembl ID

ENSG00000146426  (ver. 103.38)

Orthologs

Mouse Tiam2: ENSMUSG00000023800

UniProt

Q8IVF5

neXtProt

NX_Q8IVF5

Human splice variants
Mouse splice variants

Protein structure