Tissue expression
Cell line expression
NDRG4
gene productKIAA1180, SMAP-8
This gene is a member of the N-myc downregulated gene family which belongs to the alpha/beta hydrolase superfamily. The protein encoded by this gene is a cytoplasmic protein that is required for cell cycle progression and survival in primary astrocytes and may be involved in the regulation of mitogenic signalling in vascular smooth muscles cells. Alternative splicing results in multiple transcripts encoding different isoforms. [provided by RefSeq, Jun 2011]
- Description
- NDRG family member 4
- Tissue specificity
- Tissue enhanced (brain, heart muscle)
- Subcell location
- Nucleoplasm, Cytosol
- Predicted location
- Intracellular, Membrane
- Protein family
- Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Predicted membrane proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)
- Chromosome
- 16:q21 (58462846 - 58513628)
- Ensembl ID
- ENSG00000103034 (ver. 103.38)
- Orthologs
- Mouse Ndrg4: ENSMUSG00000036564
- UniProt
- Q9ULP0
- neXtProt
- NX_Q9ULP0
Human splice variants
Mouse splice variants
Ensembl | UniProt | RefSeq | Entrez |
---|---|---|---|
ENSMUST00000041318 ENSMUSP00000036226 |
Q8BTG7.122 Q8BTG7 | NP_001359352.1 NP_001359352 NP_001359350.1 NP_001359350 NP_001359359.1 NP_001359359 NP_001359355.1 NP_001359355 NP_001359358.1 NP_001359358 NP_001359357.1 NP_001359357 NP_001359356.1 NP_001359356 NP_001359354.1 NP_001359354 | Ndrg4 234593 |
ENSMUST00000073139 ENSMUSP00000072883 |
Q8BTG7.122 Q8BTG7 | NP_001181935.1 NP_001181935 NP_001359360.1 NP_001359360 | Ndrg4 234593 |
ENSMUST00000080666 ENSMUSP00000079495 |
Q8BTG7.122 Q8BTG7 | NP_663577.1 NP_663577 NP_001359363.1 NP_001359363 NP_001359362.1 NP_001359362 NP_001359361.1 NP_001359361 NP_001359364.1 NP_001359364 | Ndrg4 234593 |
ENSMUST00000160915 ENSMUSP00000148614 |
Ndrg4 234593 | ||
ENSMUST00000160964 ENSMUSP00000125703 |
Ndrg4 234593 | ||
ENSMUST00000162578 ENSMUSP00000148590 |
Ndrg4 234593 | ||
ENSMUST00000166358 ENSMUSP00000131203 |
Ndrg4 234593 | ||
ENSMUST00000212160 ENSMUSP00000148779 |
Ndrg4 234593 |
* nTPM: Normalized TPM levels represent consensus gene expression calculated using two data sets. Read more
RNA data sourced from Human Protein Atlas.