MLX

The product of this gene belongs to the family of basic helix-loop-helix leucine zipper (bHLH-Zip) transcription factors. These factors form heterodimers with Mad proteins and play a role in proliferation, determination and differentiation. This gene product may act to diversify Mad family function by its restricted association with a subset of the Mad family of transcriptional repressors, namely, Mad1 and Mad4. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]

Description

MAX dimerization protein MLX

Tissue specificity

Low tissue specificity

Subcell location

Nucleoplasm, Nuclear membrane, Cytosol

Predicted location

Intracellular

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Plasma proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)
Transcription factors

Chromosome

17 (42567072 - 42573239)

Ensembl ID

ENSG00000108788  (ver. 103.38)

Orthologs

Mouse Mlx: ENSMUSG00000017801

UniProt

Q9UH92

neXtProt

NX_Q9UH92

Human splice variants
Mouse splice variants

Protein structure