C5AR2

This gene encodes a G-protein coupled receptor 1 family member involved in the complement system of the innate immune response. Unlike classical G-protein coupled receptors, the encoded protein does not associate with intracellular G-proteins. It may instead modulate signal transduction through the beta-arrestin pathway, and may alternatively act as a decoy receptor. This gene may be involved in coronary artery disease and in the pathogenesis of sepsis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2012]

Description

Complement component 5a receptor 2

Tissue specificity

Tissue enhanced (lymphoid tissue)

Predicted location

Membrane

Protein family

G-protein coupled receptors
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted membrane proteins

Chromosome

19 (47332175 - 47347329)

Ensembl ID

ENSG00000134830  (ver. 103.38)

Orthologs

Mouse C5ar2: ENSMUSG00000074361

UniProt

Q9P296

neXtProt

NX_Q9P296

Human splice variants
Mouse splice variants

Protein structure