SCUBE3

gene product
CEGF3, FLJ34743
This gene encodes a member of the signal peptide, complement subcomponents C1r/C1s, Uegf, bone morphogenetic protein-1 and epidermal growth factor-like domain containing protein family. Overexpression of this gene in human embryonic kidney cells results in secretion of a glycosylated form of the protein that forms oligomers and tethers to the cell surface. This gene is upregulated in lung cancer tumor tissue compared to healthy tissue and is associated with loss of the epithelial marker E-cadherin and with increased expression of vimentin, a mesenchymal marker. In addition, the protein encoded by this gene is a transforming growth factor beta receptor ligand, and when secreted by cancer cells, it can be cleaved in vitro to release the N-terminal epidermal growth factor-like repeat domain and the C-terminal complement subcomponents C1r/C1s domain. Both the full length protein and C-terminal fragment can bind to the transforming growth factor beta type II receptor to promote the epithelial-mesenchymal transition and tumor angiogenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014]
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182 antibodies from 27 providers.

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Antibody
Proteintech Group
1 antibody
GeneTex
1 antibody
antibodies-online
58 antibodies
LifeSpan BioSciences, Inc.
30 antibodies
Novus Biologicals
4 antibodies
Boster Biological Technology
2 antibodies
NovoPro Bioscience Inc.
3 antibodies
Cusabio Biotech Co., Ltd
1 antibody
Wuhan Fine Biotech Co., Ltd.
1 antibody
OriGene
3 antibodies
Atlas Antibodies
1 antibody
Invitrogen Antibodies
3 antibodies
Biorbyt
10 antibodies
Acris Antibodies GmbH
2 antibodies
Abgent
4 antibodies
ProSci
2 antibodies
Abnova Corporation
4 antibodies
Aviva Systems Biology
2 antibodies
Rockland Immunochemicals, Inc.
2 antibodies
Creative Biolabs
4 antibodies
MyBioSource
3 antibodies
Leading Biology
4 antibodies
Creative Diagnostics
4 antibodies
RayBiotech, Inc.
3 antibodies
United States Biological
13 antibodies
Abbexa
2 antibodies