BCAR3

Breast tumors are initially dependent on estrogens for growth and progression and can be inhibited by anti-estrogens such as tamoxifen. However, breast cancers progress to become anti-estrogen resistant. Breast cancer anti-estrogen resistance gene 3 was identified in the search for genes involved in the development of estrogen resistance. The gene encodes a component of intracellular signal transduction that causes estrogen-independent proliferation in human breast cancer cells. The protein contains a putative src homology 2 (SH2) domain, a hall mark of cellular tyrosine kinase signaling molecules, and is partly homologous to the cell division cycle protein CDC48. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2012]

Description

BCAR3 adaptor protein, NSP family member

Tissue specificity

Low tissue specificity

Subcell location

Plasma membrane, Centrosome, Cytosol

Predicted location

Intracellular

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

1 (93561741 - 93847150)

Ensembl ID

ENSG00000137936  (ver. 103.38)

Orthologs

Mouse Bcar3: ENSMUSG00000028121

UniProt

O75815

neXtProt

NX_O75815

Human splice variants
Mouse splice variants

Protein structure