Tissue expression
Cell line expression
Protein structure


Solute carrier family 4 member 1 (Diego blood group)
AE1, CD233, DI, EPB3, FR, RTA1A, SW, WD, WR 
The protein encoded by this gene is part of the anion exchanger (AE) family and is expressed in the erythrocyte plasma membrane, where it functions as a chloride/bicarbonate exchanger involved in carbon dioxide transport from tissues to lungs. The protein comprises two domains that are structurally and functionally distinct. The N-terminal 40kDa domain is located in the cytoplasm and acts as an attachment site for the red cell skeleton by binding ankyrin. The glycosylated C-terminal membrane-associated domain contains 12-14 membrane spanning segments and carries out the stilbene disulphonate-sensitive exchange transport of anions. The cytoplasmic tail at the extreme C-terminus of the membrane domain binds carbonic anhydrase II. The encoded protein associates with the red cell membrane protein glycophorin A and this association promotes the correct folding and translocation of the exchanger. This protein is predominantly dimeric but forms tetramers in the presence of ankyrin. Many mutations in this gene are known in man, and these mutations can lead to two types of disease: destabilization of red cell membrane leading to hereditary spherocytosis, and defective kidney acid secretion leading to distal renal tubular acidosis. Other mutations that do not give rise to disease result in novel blood group antigens, which form the Diego blood group system. Southeast Asian ovalocytosis (SAO, Melanesian ovalocytosis) results from the heterozygous presence of a deletion in the encoded protein and is common in areas where Plasmodium falciparum malaria is endemic. One null mutation in this gene is known, resulting in very severe anemia and nephrocalcinosis. [provided by RefSeq, Jul 2008]
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364 antibodies from 36 providers.

Antibody properties


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Proteintech Group
3 antibodies
5 antibodies
Novus Biologicals
29 antibodies
Invitrogen Antibodies
18 antibodies
NSJ Bioreagents
2 antibodies
NovoPro Bioscience Inc.
1 antibody
1 antibody
Boster Biological Technology
1 antibody
31 antibodies
St John's Laboratory
3 antibodies
Wuhan Fine Biotech Co., Ltd.
2 antibodies
91 antibodies
Abnova Corporation
3 antibodies
Atlas Antibodies
2 antibodies
Aviva Systems Biology
1 antibody
Cusabio Biotech Co., Ltd
3 antibodies
Acris Antibodies GmbH
1 antibody
Affinity Biosciences
1 antibody
International Blood Group Reference Laboratory
11 antibodies
Absolute Antibody
5 antibodies
5 antibodies
6 antibodies
2 antibodies
2 antibodies
Cell Signaling Technology, Inc
2 antibodies
Creative Biolabs
35 antibodies
MilliporeSigma / Merck KGaA
4 antibodies
1 antibody
RayBiotech, Inc.
1 antibody
4 antibodies
Creative Diagnostics
3 antibodies
2 antibodies
EMD Millipore
1 antibody
United States Biological
1 antibody