Tissue expression
Cell line expression

SLC4A1

gene product
AE1, CD233, DI, EPB3, FR, RTA1A, SW, WD, WR 
The protein encoded by this gene is part of the anion exchanger (AE) family and is expressed in the erythrocyte plasma membrane, where it functions as a chloride/bicarbonate exchanger involved in carbon dioxide transport from tissues to lungs. The protein comprises two domains that are structurally and functionally distinct. The N-terminal 40kDa domain is located in the cytoplasm and acts as an attachment site for the red cell skeleton by binding ankyrin. The glycosylated C-terminal membrane-associated domain contains 12-14 membrane spanning segments and carries out the stilbene disulphonate-sensitive exchange transport of anions. The cytoplasmic tail at the extreme C-terminus of the membrane domain binds carbonic anhydrase II. The encoded protein associates with the red cell membrane protein glycophorin A and this association promotes the correct folding and translocation of the exchanger. This protein is predominantly dimeric but forms tetramers in the presence of ankyrin. Many mutations in this gene are known in man, and these mutations can lead to two types of disease: destabilization of red cell membrane leading to hereditary spherocytosis, and defective kidney acid secretion leading to distal renal tubular acidosis. Other mutations that do not give rise to disease result in novel blood group antigens, which form the Diego blood group system. Southeast Asian ovalocytosis (SAO, Melanesian ovalocytosis) results from the heterozygous presence of a deletion in the encoded protein and is common in areas where Plasmodium falciparum malaria is endemic. One null mutation in this gene is known, resulting in very severe anemia and nephrocalcinosis. [provided by RefSeq, Jul 2008]
More gene data

Featured antibodies

Antibodies

 

Filters

Application

Validation method

Reference

Provider

Host

Reactivity

Antibody type

Antigen sequence

Conjugate

Epitope

Antibody

  or   Clear
Enhanced validation
Enhanced validation
Supportive data in Antibodypedia
Data presented on provider website
Data in Antibodypedia (inconclusive)
325 antibodies from 35 providers.

Antibody properties

Applications

or Cancel
AntibodyRefsTypeWBELICCIPIHCFC
GeneTex
5 antibodies
Novus Biologicals
29 antibodies
Proteintech Group
2 antibodies
NSJ Bioreagents
2 antibodies
NovoPro Bioscience Inc.
1 antibody
LifeSpan BioSciences, Inc.
42 antibodies
Arigo
1 antibody
Boster Biological Technology
1 antibody
Invitrogen Antibodies
7 antibodies
Wuhan Fine Biotech Co., Ltd.
2 antibodies
antibodies-online
91 antibodies
Abnova Corporation
3 antibodies
Aviva Systems Biology
1 antibody
Cusabio Biotech Co., Ltd
3 antibodies
Biorbyt
11 antibodies
Acris Antibodies GmbH
1 antibody
Affinity Biosciences
1 antibody
International Blood Group Reference Laboratory
11 antibodies
Absolute Antibody
5 antibodies
Creative Biolabs
31 antibodies
OriGene
5 antibodies
Atlas Antibodies
2 antibodies
RabMAbs
6 antibodies
ProSci
2 antibodies
GenWay
2 antibodies
Cell Signaling Technology, Inc
2 antibodies
MilliporeSigma / Merck KGaA
4 antibodies
Abgent
1 antibody
RayBiotech, Inc.
1 antibody
Abbexa
4 antibodies
Creative Diagnostics
3 antibodies
MyBioSource
2 antibodies
EMD Millipore
1 antibody
United States Biological
1 antibody