SPAM1

gene product
HYAL5, PH-20, SPAG15
Hyaluronidase degrades hyaluronic acid, a major structural proteoglycan found in extracellular matrices and basement membranes. Six members of the hyaluronidase family are clustered into two tightly linked groups on chromosome 3p21.3 and 7q31.3. This gene was previously referred to as HYAL1 and HYA1 and has since been assigned the official symbol SPAM1; another family member on chromosome 3p21.3 has been assigned HYAL1. This gene encodes a GPI-anchored enzyme located on the human sperm surface and inner acrosomal membrane. This multifunctional protein is a hyaluronidase that enables sperm to penetrate through the hyaluronic acid-rich cumulus cell layer surrounding the oocyte, a receptor that plays a role in hyaluronic acid induced cell signaling, and a receptor that is involved in sperm-zona pellucida adhesion. Abnormal expression of this gene in tumors has implicated this protein in degradation of basement membranes leading to tumor invasion and metastasis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2010]
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176 antibodies from 23 providers.

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AntibodyRefsTypeWBELICCIPIHCFC
Atlas Antibodies
1 antibody
antibodies-online
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Bioworld Technology, Inc
1 antibody
Biorbyt
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Affinity Biosciences
1 antibody
LifeSpan BioSciences, Inc.
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OriGene
2 antibodies
Abnova Corporation
2 antibodies
GeneTex
1 antibody
Novus Biologicals
1 antibody
Invitrogen Antibodies
3 antibodies
NovoPro Bioscience Inc.
3 antibodies
Abbexa
4 antibodies
St John's Laboratory
1 antibody
Proteintech Group
1 antibody
Aviva Systems Biology
3 antibodies
Abgent
2 antibodies
United States Biological
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Creative Biolabs
3 antibodies
MyBioSource
2 antibodies
Boster Biological Technology
1 antibody
Creative Diagnostics
3 antibodies
Sigma-Aldrich
1 antibody