Tissue expression
Cell line expression
Protein structure
FBXW2
F-box and WD repeat domain containing 2FBW2, Fwd2, Md6
F-box proteins are an expanding family of eukaryotic proteins characterized by an approximately 40 amino acid motif, the F box. Some F-box proteins have been shown to be critical for the ubiquitin-mediated degradation of cellular regulatory proteins. In fact, F-box proteins are one of the four subunits of ubiquitin protein ligases, called SCFs. SCF ligases bring ubiquitin conjugating enzymes to substrates that are specifically recruited by the different F-box proteins. Mammalian F-box proteins are classified into three groups based on the presence of either WD-40 repeats, leucine-rich repeats, or the presence or absence of other protein-protein interacting domains. This gene encodes the second identified member of the F-box gene family and contains multiple WD-40 repeats. [provided by RefSeq, Jul 2008]
Top validated antibodies |
|||||
Proteintech Group | ![]() |
7 references | Polyclonal |
|
|
Novus Biologicals | ![]() |
1 references | Polyclonal |
|
|
Invitrogen Antibodies | ![]() |
1 references | Polyclonal |
|
|
antibodies-online | ![]() |
1 references | Polyclonal |
|
|
Acris Antibodies GmbH | ![]() |
Polyclonal |
|