GSTA2

gene product
GST2
Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. These enzymes function in the detoxification of electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins and products of oxidative stress, by conjugation with glutathione. The genes encoding these enzymes are known to be highly polymorphic. These genetic variations can change an individual's susceptibility to carcinogens and toxins as well as affect the toxicity and efficacy of some drugs. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a glutathione S-tranferase belonging to the alpha class. The alpha class genes, located in a cluster mapped to chromosome 6, are the most abundantly expressed glutathione S-transferases in liver. In addition to metabolizing bilirubin and certain anti-cancer drugs in the liver, the alpha class of these enzymes exhibit glutathione peroxidase activity thereby protecting the cells from reactive oxygen species and the products of peroxidation. [provided by RefSeq, Jul 2008]
More gene data

Featured antibodies

Antibodies

 

Filters

Application

Antibodypedia Validation Initiative

Validation method

Reference

Provider

Host

Reactivity

Antibody type

Conjugate

Antibody

  or   Clear
Enhanced validation
Enhanced validation
Supportive data in Antibodypedia
Data presented on provider website
Data in Antibodypedia (inconclusive)
Validated within AVI
Eligible for validation within AVI
208 antibodies from 25 providers.

Antibody properties

General

Applications

or Cancel
Antibody
GeneTex
3 antibodies
Novus Biologicals
4 antibodies
antibodies-online
77 antibodies
Aviva Systems Biology
6 antibodies
LifeSpan BioSciences, Inc.
55 antibodies
OriGene
3 antibodies
Abnova Corporation
4 antibodies
Invitrogen Antibodies
3 antibodies
Signalway Antibody LLC
2 antibodies
NovoPro Bioscience Inc.
3 antibodies
Proteintech Group
1 antibody
Biorbyt
11 antibodies
Abgent
1 antibody
Acris Antibodies GmbH
1 antibody
Abbexa
1 antibody
St John's Laboratory
1 antibody
MyBioSource
5 antibodies
Creative Diagnostics
5 antibodies
Affinity Biosciences
1 antibody
Boster Biological Technology
1 antibody
RabMAbs
1 antibody
RayBiotech, Inc.
1 antibody
United States Biological
15 antibodies
Creative Biolabs
1 antibody
Sigma-Aldrich
2 antibodies