Tissue expression
Cell line expression
Protein structure
ANAPC5
Anaphase promoting complex subunit 5APC5
This gene encodes a tetratricopeptide repeat-containing component of the anaphase promoting complex/cyclosome (APC/C), a large E3 ubiquitin ligase that controls cell cycle progression by targeting a number of cell cycle regulators such as B-type cyclins for 26S proteasome-mediated degradation through ubiquitination. The encoded protein is required for the proper ubiquitination function of APC/C and for the interaction of APC/C with transcription coactivators. It also interacts with polyA binding protein and represses internal ribosome entry site-mediated translation. Multiple transcript variants encoding different isoforms have been found for this gene. These differences cause translation initiation at a downstream AUG and result in a shorter protein (isoform b), compared to isoform a. [provided by RefSeq, Nov 2008]
Top validated antibodies |
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GeneTex | GTX17060 | Polyclonal |
WB
EL
ICC
IHC |
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Invitrogen Antibodies | PA5-96581 | Polyclonal |
WB
IP
IHC
OA |
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NSJ Bioreagents | RQ6121 | Polyclonal |
WB
EL
ICC
FC |
||
Novus Biologicals | NBP1-77154 | Polyclonal |
WB
EL
ICC
IHC |
||
Boster Biological Technology | A08280-1 | Polyclonal |
WB
EL
ICC
IHC |
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