EFCAB6

This gene encodes a protein which directly binds the oncogene DJ-1 and androgen receptor to form a ternary complex in cells. This binding protein recruits histone-deacetylase complexes in order to repress transcription activity of androgen receptor. This protein may also play a role in spermatogenesis and fertilization. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]

Description

EF-hand calcium binding domain 6

Tissue specificity

Tissue enhanced (testis)

Subcell location

Nucleoplasm

Predicted location

Intracellular

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Protein evidence (Kim et al 2014)

Chromosome

22 (43528744 - 43812337)

Ensembl ID

ENSG00000186976  (ver. 103.38)

Orthologs

Mouse Efcab6: ENSMUSG00000022441

UniProt

Q5THR3

neXtProt

NX_Q5THR3

Human splice variants
Mouse splice variants

Protein structure