Tissue expression
Cell line expression
Protein structure

PLG

Plasminogen
 
The plasminogen protein encoded by this gene is a serine protease that circulates in blood plasma as an inactive zymogen and is converted to the active protease, plasmin, by several plasminogen activators such as tissue plasminogen activator (tPA), urokinase plasminogen activator (uPA), kallikrein, and factor XII (Hageman factor). The conversion of plasminogen to plasmin involves the cleavage of the peptide bond between Arg-561 and Val-562. Plasmin cleavage also releases the angiostatin protein which inhibits angiogenesis. Plasmin degrades many blood plasma proteins, including fibrin-containing blood clots. As a serine protease, plasmin cleaves many products in addition to fibrin such as fibronectin, thrombospondin, laminin, and von Willebrand factor. Plasmin is inactivated by proteins such as alpha-2-macroglobulin and alpha-2-antiplasmin in addition to inhibitors of the various plasminogen activators. Plasminogen also interacts with plasminogen receptors which results in the retention of plasmin on cell surfaces and in plasmin-induced cell signaling. The localization of plasminogen on cell surfaces plays a role in the degradation of extracellular matrices, cell migration, inflamation, wound healing, oncogenesis, metastasis, myogenesis, muscle regeneration, neurite outgrowth, and fibrinolysis. This protein may also play a role in acute respiratory distress syndrome (ARDS) which, in part, is caused by enhanced clot formation and the suppression of fibrinolysis. Compared to other mammals, the cluster of plasminogen-like genes to which this gene belongs has been rearranged in catarrhine primates. [provided by RefSeq, May 2020]
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1472 antibodies from 43 providers.

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AntibodyRefsTypeWBELICCIPIHCFC
Invitrogen Antibodies
48 antibodies
Novus Biologicals
129 antibodies
Proteintech Group
5 antibodies
Boster Biological Technology
5 antibodies
antibodies-online
497 antibodies
Aviva Systems Biology
15 antibodies
OriGene
29 antibodies
Biorbyt
174 antibodies
GeneTex
36 antibodies
NovoPro Bioscience Inc.
3 antibodies
Abgent
4 antibodies
R&D Systems
8 antibodies
Acris Antibodies GmbH
38 antibodies
Abnova Corporation
24 antibodies
FineTest Biotech
3 antibodies
Cusabio Biotech Co., Ltd
10 antibodies
Affinity Biosciences
1 antibody
Rockland Immunochemicals, Inc.
10 antibodies
Atlas Antibodies
2 antibodies
Aladdin Scientific
1 antibody
St John's Laboratory
3 antibodies
NSJ Bioreagents
2 antibodies
ProSci
2 antibodies
Green Mountain Antibodies
4 antibodies
RabMAbs
1 antibody
MyBioSource
33 antibodies
Creative Biolabs
22 antibodies
Abbkine Scientific Co.Ltd.
2 antibodies
Creative Diagnostics
22 antibodies
Abbexa
11 antibodies
RayBiotech, Inc.
2 antibodies
GenWay
9 antibodies
Bioworld Technology, Inc
1 antibody
Cell Signaling Technology, Inc
1 antibody
Molecular Innovations
14 antibodies
United States Biological
34 antibodies
Leading Biology
4 antibodies
Academy Bio-Medical Co.
7 antibodies
MilliporeSigma / Merck KGaA
7 antibodies
EMD Millipore
1 antibody
Exalpha Biologicals, Inc.
5 antibodies