RAET1E

This gene belong to the RAET1 family, which consists of major histocompatibility complex (MHC) class I-related genes located in a cluster on chromosome 6q24.2-q25.3. This and RAET1G protein differ from other RAET1 proteins in that they have type I membrane-spanning sequences at their C termini rather than glycosylphosphatidylinositol anchor sequences. This protein functions as a ligand for NKG2D receptor, which is expressed on the surface of several types of immune cells, and is involved in innate and adaptive immune responses. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]

Description

Retinoic acid early transcript 1E

Tissue specificity

Tissue enhanced (esophagus, skin , vagina)

Subcell location

Focal adhesion sites, Cytosol

Predicted location

Intracellular, Membrane

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Predicted membrane proteins

Chromosome

6 (149883375 - 149898102)

Ensembl ID

ENSG00000164520  (ver. 103.38)

Orthologs

-

UniProt

Q8TD07

neXtProt

NX_Q8TD07

Human splice variants

Protein structure