Tissue expression
Cell line expression
Protein structure
RYK
Receptor like tyrosine kinaseD3S3195, JTK5, JTK5A, RYK1
The protein encoded by this gene is an atypical member of the family of growth factor receptor protein tyrosine kinases, differing from other members at a number of conserved residues in the activation and nucleotide binding domains. This gene product belongs to a subfamily whose members do not appear to be regulated by phosphorylation in the activation segment. It has been suggested that mediation of biological activity by recruitment of a signaling-competent auxiliary protein may occur through an as yet uncharacterized mechanism. The encoded protein has a leucine-rich extracellular domain with a WIF-type Wnt binding region, a single transmembrane domain, and an intracellular tyrosine kinase domain. This protein is involved in stimulating Wnt signaling pathways such as the regulation of axon pathfinding. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Feb 2012]
Top validated antibodies |
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R&D Systems | AF4649 | 1 references | Polyclonal |
WB
ICC
FC
|
|
Invitrogen Antibodies | PA1-30319 | 1 references | Polyclonal |
WB
IHC
OA
|
|
Novus Biologicals | AF4649 | 1 references | Polyclonal |
WB
ICC
FC
|
|
Biorbyt | orb1726933 | Recombinant |
WB
ICC
IP
IHC
FC
|
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Proteintech Group | 22138-1-AP | Polyclonal |
WB
EL
ICC
IHC |
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Enhanced validation
Supportive data in Antibodypedia
Data presented on provider website
Data in Antibodypedia (inconclusive)
Recommended by provider
Supportive data in Antibodypedia
Data presented on provider website
Data in Antibodypedia (inconclusive)
Recommended by provider