Tissue expression
Cell line expression
Protein structure
PLN
PhospholambanCMD1P, PLB
The protein encoded by this gene is found as a pentamer and is a major substrate for the cAMP-dependent protein kinase in cardiac muscle. The encoded protein is an inhibitor of cardiac muscle sarcoplasmic reticulum Ca(2+)-ATPase in the unphosphorylated state, but inhibition is relieved upon phosphorylation of the protein. The subsequent activation of the Ca(2+) pump leads to enhanced muscle relaxation rates, thereby contributing to the inotropic response elicited in heart by beta-agonists. The encoded protein is a key regulator of cardiac diastolic function. Mutations in this gene are a cause of inherited human dilated cardiomyopathy with refractory congestive heart failure, and also familial hypertrophic cardiomyopathy. [provided by RefSeq, Apr 2016]
Top validated antibodies |
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Invitrogen Antibodies | ![]() |
176 references | Monoclonal |
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GeneTex | ![]() |
1 references | Monoclonal |
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antibodies-online | ![]() |
5 references | Monoclonal |
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Novus Biologicals | ![]() |
1 references | Polyclonal |
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Badrilla Ltd | ![]() |
106 references | Polyclonal |
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