PRKAA2

The protein encoded by this gene is a catalytic subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. Studies of the mouse counterpart suggest that this catalytic subunit may control whole-body insulin sensitivity and is necessary for maintaining myocardial energy homeostasis during ischemia. [provided by RefSeq, Jul 2008]

Description

Protein kinase AMP-activated catalytic subunit alpha 2

Tissue specificity

Tissue enhanced (heart muscle, skeletal muscle, tongue)

Subcell location

Nuclear speckles, Golgi apparatus

Predicted location

Membrane

Protein family

Enzymes
FDA approved drug targets
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Metabolic proteins
Predicted membrane proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)
Transporters

Chromosome

1 (56645314 - 56715335)

Ensembl ID

ENSG00000162409  (ver. 103.38)

Orthologs

Mouse Prkaa2: ENSMUSG00000028518

UniProt

P54646

neXtProt

NX_P54646

Human splice variants
Mouse splice variants

Protein structure