Tissue expression
Cell line expression
Protein structure

PIKFYVE

Phosphoinositide kinase, FYVE-type zinc finger containing
FAB1, KIAA0981, MGC40423, p235, PIP5K, PIP5K3, ZFYVE29 
Phosphorylated derivatives of phosphatidylinositol (PtdIns) regulate cytoskeletal functions, membrane trafficking, and receptor signaling by recruiting protein complexes to cell- and endosomal-membranes. Humans have multiple PtdIns proteins that differ by the degree and position of phosphorylation of the inositol ring. This gene encodes an enzyme (PIKfyve; also known as phosphatidylinositol-3-phosphate 5-kinase type III or PIPKIII) that phosphorylates the D-5 position in PtdIns and phosphatidylinositol-3-phosphate (PtdIns3P) to make PtdIns5P and PtdIns(3,5)biphosphate. The D-5 position also can be phosphorylated by type I PtdIns4P-5-kinases (PIP5Ks) that are encoded by distinct genes and preferentially phosphorylate D-4 phosphorylated PtdIns. In contrast, PIKfyve preferentially phosphorylates D-3 phosphorylated PtdIns. In addition to being a lipid kinase, PIKfyve also has protein kinase activity. PIKfyve regulates endomembrane homeostasis and plays a role in the biogenesis of endosome carrier vesicles from early endosomes. Mutations in this gene cause corneal fleck dystrophy (CFD); an autosomal dominant disorder characterized by numerous small white flecks present in all layers of the corneal stroma. Histologically, these flecks appear to be keratocytes distended with lipid and mucopolysaccharide filled intracytoplasmic vacuoles. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, May 2010]
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429 antibodies from 34 providers.

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AntibodyRefsTypeWBELICCIPIHCFC
Novus Biologicals
5 antibodies
Abnova Corporation
8 antibodies
antibodies-online
105 antibodies
Invitrogen Antibodies
24 antibodies
Proteintech Group
1 antibody
Biorbyt
65 antibodies
NovoPro Bioscience Inc.
2 antibodies
Abgent
1 antibody
St John's Laboratory
4 antibodies
Cusabio Biotech Co., Ltd
8 antibodies
Boster Biological Technology
5 antibodies
Aviva Systems Biology
3 antibodies
Acris Antibodies GmbH
4 antibodies
GeneTex
2 antibodies
OriGene
16 antibodies
Bioworld Technology, Inc
1 antibody
Affinity Biosciences
1 antibody
FineTest Biotech
1 antibody
Abbkine Scientific Co.Ltd.
3 antibodies
Atlas Antibodies
1 antibody
ProSci
1 antibody
R&D Systems
1 antibody
United States Biological
45 antibodies
Abbexa
11 antibodies
MyBioSource
6 antibodies
MilliporeSigma / Merck KGaA
3 antibodies
Leading Biology
2 antibodies
RabMAbs
1 antibody
Creative Biolabs
21 antibodies
Absolute Antibody
7 antibodies
Abbiotec
1 antibody
Creative Diagnostics
2 antibodies
Rockland Immunochemicals, Inc.
1 antibody