Tissue expression
Cell line expression
Protein structure
PIKFYVE
Phosphoinositide kinase, FYVE-type zinc finger containingFAB1, KIAA0981, MGC40423, p235, PIP5K, PIP5K3, ZFYVE29
Phosphorylated derivatives of phosphatidylinositol (PtdIns) regulate cytoskeletal functions, membrane trafficking, and receptor signaling by recruiting protein complexes to cell- and endosomal-membranes. Humans have multiple PtdIns proteins that differ by the degree and position of phosphorylation of the inositol ring. This gene encodes an enzyme (PIKfyve; also known as phosphatidylinositol-3-phosphate 5-kinase type III or PIPKIII) that phosphorylates the D-5 position in PtdIns and phosphatidylinositol-3-phosphate (PtdIns3P) to make PtdIns5P and PtdIns(3,5)biphosphate. The D-5 position also can be phosphorylated by type I PtdIns4P-5-kinases (PIP5Ks) that are encoded by distinct genes and preferentially phosphorylate D-4 phosphorylated PtdIns. In contrast, PIKfyve preferentially phosphorylates D-3 phosphorylated PtdIns. In addition to being a lipid kinase, PIKfyve also has protein kinase activity. PIKfyve regulates endomembrane homeostasis and plays a role in the biogenesis of endosome carrier vesicles from early endosomes. Mutations in this gene cause corneal fleck dystrophy (CFD); an autosomal dominant disorder characterized by numerous small white flecks present in all layers of the corneal stroma. Histologically, these flecks appear to be keratocytes distended with lipid and mucopolysaccharide filled intracytoplasmic vacuoles. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, May 2010]
Top validated antibodies |
|||||
Novus Biologicals | H00200576-M01 | 3 references | Monoclonal |
WB
EL
ICC
IP
IHC
BN |
|
Abnova Corporation | H00200576-M01 | 2 references | Monoclonal |
WB
EL
ICC
IHC |
|
antibodies-online | ABIN566937 | 2 references | Monoclonal |
WB
EL
ICC
IHC |
|
Proteintech Group | 13361-1-AP | 8 references | Polyclonal |
WB
EL
IHC
|
|
Invitrogen Antibodies | H00200576-M01 | Monoclonal |
WB
EL
ICC
IHC |
All Antibodies
Filters
Enhanced validation
Supportive data in Antibodypedia
Data presented on provider website
Data in Antibodypedia (inconclusive)
Recommended by provider
Supportive data in Antibodypedia
Data presented on provider website
Data in Antibodypedia (inconclusive)
Recommended by provider