Tissue expression
Cell line expression
Protein structure
HDAC5
Histone deacetylase 5FLJ90614, KIAA0600, NY-CO-9
Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to the class II histone deacetylase/acuc/apha family. It possesses histone deacetylase activity and represses transcription when tethered to a promoter. It coimmunoprecipitates only with HDAC3 family member and might form multicomplex proteins. It also interacts with myocyte enhancer factor-2 (MEF2) proteins, resulting in repression of MEF2-dependent genes. This gene is thought to be associated with colon cancer. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Top validated antibodies |
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antibodies-online | ABIN393805 | 5 references | Monoclonal |
WB
EL
ICC
IHC |
|
Boster Biological Technology | A01230-6 | 1 references | Polyclonal |
WB
EL
ICC
IHC
FC
|
|
Novus Biologicals | NBP2-22152 | 2 references | Polyclonal |
WB
ICC
IHC
ChIP |
|
NSJ Bioreagents | RQ5816 | Polyclonal |
WB
EL
ICC
IHC
FC
|
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LSBio | LS-C353225 | Polyclonal |
WB
ICC
IP
IHC |
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