Tissue expression
Cell line expression
Protein structure
NDUFS2
NADH:ubiquinone oxidoreductase core subunit S2CI-49
The protein encoded by this gene is a core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (complex I). Mammalian mitochondrial complex I is composed of at least 43 different subunits, 7 of which are encoded by the mitochondrial genome, and the rest are the products of nuclear genes. The iron-sulfur protein fraction of complex I is made up of 7 subunits, including this gene product. Complex I catalyzes the NADH oxidation with concomitant ubiquinone reduction and proton ejection out of the mitochondria. Mutations in this gene are associated with mitochondrial complex I deficiency. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009]
Top validated antibodies |
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Invitrogen Antibodies | ![]() |
2 references | Polyclonal |
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LSBio | ![]() |
Polyclonal |
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NSJ Bioreagents | ![]() |
Polyclonal |
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GeneTex | ![]() |
1 references | Polyclonal |
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Biorbyt | ![]() |
Polyclonal |
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