HSD11B1

gene product
HSD11, HSD11B, SDR26C1
The protein encoded by this gene is a microsomal enzyme that catalyzes the conversion of the stress hormone cortisol to the inactive metabolite cortisone. In addition, the encoded protein can catalyze the reverse reaction, the conversion of cortisone to cortisol. Too much cortisol can lead to central obesity, and a particular variation in this gene has been associated with obesity and insulin resistance in children. Mutations in this gene and H6PD (hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase)) are the cause of cortisone reductase deficiency. Alternate splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, May 2011]
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HUABIO Research
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MyBioSource
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Leading Biology
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RayBiotech, Inc.
1 antibody
Rockland Immunochemicals, Inc.
1 antibody
Enzo Life Sciences
3 antibodies
Abgent
2 antibodies