TNFSF12

gene product
APO3L, DR3LG, TWEAK
The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein is a ligand for the FN14/TWEAKR receptor. This cytokine has overlapping signaling functions with TNF, but displays a much wider tissue distribution. This cytokine, which exists in both membrane-bound and secreted forms, can induce apoptosis via multiple pathways of cell death in a cell type-specific manner. This cytokine is also found to promote proliferation and migration of endothelial cells, and thus acts as a regulator of angiogenesis. Alternative splicing results in multiple transcript variants. Some transcripts skip the last exon of this gene and continue into the second exon of the neighboring TNFSF13 gene; such read-through transcripts are contained in GeneID 407977, TNFSF12-TNFSF13. [provided by RefSeq, Oct 2010]
More gene data

Featured antibodies

Antibodies

 

Filters

Application

Antibodypedia Validation Initiative

Validation method

Reference

Provider

Host

Reactivity

Antibody type

Conjugate

Antibody

  or   Clear
Enhanced validation
Enhanced validation
Supportive data in Antibodypedia
Data presented on provider website
Data in Antibodypedia (inconclusive)
Validated within AVI
Eligible for validation within AVI
532 antibodies from 38 providers.

Antibody properties

General

Applications

or Cancel
Antibody
Novus Biologicals
31 antibodies
Invitrogen Antibodies
11 antibodies
R&D Systems
6 antibodies
antibodies-online
139 antibodies
Biorbyt
29 antibodies
Abnova Corporation
6 antibodies
Aviva Systems Biology
6 antibodies
LifeSpan BioSciences, Inc.
107 antibodies
Affinity Biosciences
3 antibodies
OriGene
8 antibodies
Bioworld Technology, Inc
2 antibodies
Acris Antibodies GmbH
12 antibodies
Boster Biological Technology
2 antibodies
GeneTex
6 antibodies
PeproTech Inc.
8 antibodies
Antibodies.com
3 antibodies
Abgent
4 antibodies
Creative Biolabs
38 antibodies
ProSci
6 antibodies
St John's Laboratory
2 antibodies
Abbkine Scientific Co.Ltd.
1 antibody
Proteintech Group
1 antibody
NSJ Bioreagents
1 antibody
MyBioSource
11 antibodies
RayBiotech, Inc.
2 antibodies
Atlas Antibodies
1 antibody
Rockland Immunochemicals, Inc.
1 antibody
United States Biological
53 antibodies
Miltenyi Biotec
5 antibodies
Creative Diagnostics
11 antibodies
Enzo Life Sciences
2 antibodies
Abbiotec
1 antibody
Cell Signaling Technology, Inc
1 antibody
Abbexa
3 antibodies
eBioscience, An Affymetrix Company
3 antibodies
Sigma-Aldrich
4 antibodies
Leading Biology
1 antibody
EMD Millipore
1 antibody