ALPP

The protein encoded by this gene is an alkaline phosphatase, a metalloenzyme that catalyzes the hydrolysis of phosphoric acid monoesters. It belongs to a multigene family composed of four alkaline phosphatase isoenzymes. The enzyme functions as a homodimer and has a catalytic site containing one magnesium and two zinc ions, which are required for its enzymatic function. The protein is primarily expressed in placental and endometrial tissue; however, strong ectopic expression has been detected in ovarian adenocarcinoma, serous cystadenocarcinoma, and other ovarian cancer cells. [provided by RefSeq, Jan 2015]

Description

alkaline phosphatase, placental

Protein family

Cancer-related genes, Enzymes, Mapped to UniProt SWISS-PROT, Plasma proteins, Predicted secreted proteins, Protein evidence (Ezkurdia et al 2014), Protein evidence (Kim et al 2014)

Chromosome

2:q37.1 (232378534 - 232382889)

Ensembl ID

ENSG00000163283  (ver. 84.38)

Orthologs

-

UniProt

P05187

neXtProt

NX_P05187

Human splice variants