200-301-400
antibody from Rockland Immunochemicals, Inc.
Targeting: ATM
ATA, ATC, ATD, ATDC, TEL1, TELO1
Antibody data
- Antibody Data
- Antigen structure
- References [118]
- Comments [0]
- Validations [0]
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- Product number
- 200-301-400 - Provider product page
- Provider
- Rockland Immunochemicals, Inc.
- Proper citation
- Rockland Cat#200-301-400, RRID:AB_217868
- Product name
- Anti-ATM Protein Kinase pS1981 (MOUSE) Monoclonal Antibody - 200-301-400
- Antibody type
- Monoclonal
- Vial size
- 100 µl
Submitted references MRN-dependent and independent pathways for recruitment of TOPBP1 to DNA double-strand breaks.
Chemotherapy of HER2- and MDM2-Enriched Breast Cancer Subtypes Induces Homologous Recombination DNA Repair and Chemoresistance.
Class 1 Histone Deacetylases and Ataxia-Telangiectasia Mutated Kinase Control the Survival of Murine Pancreatic Cancer Cells upon dNTP Depletion.
HMGB1 signaling phosphorylates Ku70 and impairs DNA damage repair in Alzheimer's disease pathology.
Inhibition of DNA replication initiation by silver nanoclusters.
DROSHA is recruited to DNA damage sites by the MRN complex to promote non-homologous end joining.
DNA damage in embryonic neural stem cell determines FTLDs' fate via early-stage neuronal necrosis.
SLX4-XPF mediates DNA damage responses to replication stress induced by DNA-protein interactions.
Structure-function analysis of TOPBP1's role in ATR signaling using the DSB-mediated ATR activation in Xenopus egg extracts (DMAX) system.
IFI16 inhibits DNA repair that potentiates type-I interferon-induced antitumor effects in triple negative breast cancer.
Evading immune surveillance via tyrosine phosphorylation of nuclear PCNA.
Pb induced mitochondrial fission of fibroblast cells via ATM activation.
Keap1 inhibition sensitizes head and neck squamous cell carcinoma cells to ionizing radiation via impaired non-homologous end joining and induced autophagy.
ATM Inhibitor Suppresses Gemcitabine-Resistant BTC Growth in a Polymerase θ Deficiency-Dependent Manner.
ATM is a key driver of NF-κB-dependent DNA-damage-induced senescence, stem cell dysfunction and aging.
Phospho-Ser(784)-VCP Is Required for DNA Damage Response and Is Associated with Poor Prognosis of Chemotherapy-Treated Breast Cancer.
Dianhydrogalactitol synergizes with topoisomerase poisons to overcome DNA repair activity in tumor cells.
Panobinostat and venetoclax enhance the cytotoxicity of gemcitabine, busulfan, and melphalan in multiple myeloma cells.
FBXW7 Confers Radiation Survival by Targeting p53 for Degradation.
Association of glomerular DNA damage and DNA methylation with one-year eGFR decline in IgA nephropathy.
SCF(β-TrCP)-mediated degradation of TOP2β promotes cancer cell survival in response to chemotherapeutic drugs targeting topoisomerase II.
Targeting DNA-dependent protein kinase sensitizes hepatocellular carcinoma cells to proton beam irradiation through apoptosis induction.
ATM controls DNA repair and mitochondria transfer between neighboring cells.
Assessment of epigenetic mechanisms and DNA double-strand break repair using laser micro-irradiation technique developed for hematological cells.
ATM phosphorylation of the actin-binding protein drebrin controls oxidation stress-resistance in mammalian neurons and C. elegans.
PPARγ Interaction with UBR5/ATMIN Promotes DNA Repair to Maintain Endothelial Homeostasis.
CSB promoter downregulation via histone H3 hypoacetylation is an early determinant of replicative senescence.
Cell-based chemical fingerprinting identifies telomeres and lamin A as modifiers of DNA damage response in cancer cells.
Dianhydrogalactitol induces replication-dependent DNA damage in tumor cells preferentially resolved by homologous recombination.
Transcription and mRNA export machineries SAGA and TREX-2 maintain monoubiquitinated H2B balance required for DNA repair.
Epigenetic modification enhances the cytotoxicity of busulfan and4-hydroperoxycyclophosphamide in AML cells.
Distinct roles of ATM and ATR in the regulation of ARP8 phosphorylation to prevent chromosome translocations.
DNA Repair Network Analysis Reveals Shieldin as a Key Regulator of NHEJ and PARP Inhibitor Sensitivity.
PTEN deletion in luminal cells of mature prostate induces replication stress and senescence in vivo.
Lead (Pb) induced ATM-dependent mitophagy via PINK1/Parkin pathway.
HDAC1 and HDAC2 integrate checkpoint kinase phosphorylation and cell fate through the phosphatase-2A subunit PR130.
The Augmented R-Loop Is a Unifying Mechanism for Myelodysplastic Syndromes Induced by High-Risk Splicing Factor Mutations.
GFI1 facilitates efficient DNA repair by regulating PRMT1 dependent methylation of MRE11 and 53BP1.
BRCA2 suppresses replication stress-induced mitotic and G1 abnormalities through homologous recombination.
The PARP inhibitor olaparib enhances the cytotoxicity of combined gemcitabine, busulfan and melphalan in lymphoma cells.
LRRK2 interacts with ATM and regulates Mdm2-p53 cell proliferation axis in response to genotoxic stress.
Coumarin-chalcone hybrid instigates DNA damage by minor groove binding and stabilizes p53 through post translational modifications.
Oridonin promotes G2/M arrest in A549 cells by facilitating ATM activation.
Damage-induced lncRNAs control the DNA damage response through interaction with DDRNAs at individual double-strand breaks.
DNA single-strand break-induced DNA damage response causes heart failure.
Epigenetic therapy with inhibitors of histone methylation suppresses DNA damage signaling and increases glioma cell radiosensitivity.
Impaired 53BP1/RIF1 DSB mediated end-protection stimulates CtIP-dependent end resection and switches the repair to PARP1-dependent end joining in G1.
UV-dependent phosphorylation of COP9/signalosome in UV-induced apoptosis.
Redox regulation of SUMO enzymes is required for ATM activity and survival in oxidative stress.
SCAI promotes DNA double-strand break repair in distinct chromosomal contexts.
Mutant IDH1 Downregulates ATM and Alters DNA Repair and Sensitivity to DNA Damage Independent of TET2.
ATM mediates spermidine-induced mitophagy via PINK1 and Parkin regulation in human fibroblasts.
DNA Damage Signaling Is Induced in the Absence of Epstein-Barr Virus (EBV) Lytic DNA Replication and in Response to Expression of ZEBRA.
Recruitment and activation of the ATM kinase in the absence of DNA-damage sensors.
Role of the Exocyst Complex Component Sec6/8 in Genomic Stability.
Notch is a direct negative regulator of the DNA-damage response.
Stemness factor Sall4 is required for DNA damage response in embryonic stem cells.
CDK1 inhibition targets the p53-NOXA-MCL1 axis, selectively kills embryonic stem cells, and prevents teratoma formation.
Comparison of the cytotoxicity of cladribine and clofarabine when combined with fludarabine and busulfan in AML cells: Enhancement of cytotoxicity with epigenetic modulators.
Dgcr8 and Dicer are essential for sex chromosome integrity during meiosis in males.
The complexity of DNA double strand break is a crucial factor for activating ATR signaling pathway for G2/M checkpoint regulation regardless of ATM function.
Murine Gammaherpesvirus 68 LANA and SOX Homologs Counteract ATM-Driven p53 Activity during Lytic Viral Replication.
Expression of the genetic suppressor element 24.2 (GSE24.2) decreases DNA damage and oxidative stress in X-linked dyskeratosis congenita cells.
Stable cellular senescence is associated with persistent DDR activation.
A separable domain of the p150 subunit of human chromatin assembly factor-1 promotes protein and chromosome associations with nucleoli.
SETD2 is required for DNA double-strand break repair and activation of the p53-mediated checkpoint.
BRCA1 establishes DNA damage signaling and pericentric heterochromatin of the X chromosome in male meiosis.
Ribosomal S6 Kinase 2 (RSK2) maintains genomic stability by activating the Atm/p53-dependent DNA damage pathway.
Poly(ADP-ribose) binding to Chk1 at stalled replication forks is required for S-phase checkpoint activation.
ATR prohibits replication catastrophe by preventing global exhaustion of RPA.
Telomere crisis in kidney epithelial cells promotes the acquisition of a microRNA signature retrieved in aggressive renal cell carcinomas.
Sodium tungstate modulates ATM function upon DNA damage.
Detection of impaired homologous recombination repair in NSCLC cells and tissues.
The bromodomain protein Brd4 insulates chromatin from DNA damage signalling.
The telomere deprotection response is functionally distinct from the genomic DNA damage response.
BMS-345541 sensitizes MCF-7 breast cancer cells to ionizing radiation by selective inhibition of homologous recombinational repair of DNA double-strand breaks.
ATM mediates pRB function to control DNMT1 protein stability and DNA methylation.
DNA structure-specific priming of ATR activation by DNA-PKcs.
Threonine 2609 phosphorylation of the DNA-dependent protein kinase is a critical prerequisite for epidermal growth factor receptor-mediated radiation resistance.
Nuclear lamina defects cause ATM-dependent NF-κB activation and link accelerated aging to a systemic inflammatory response.
CUX1 transcription factor is required for optimal ATM/ATR-mediated responses to DNA damage.
The DNA damage checkpoint protein ATM promotes hepatocellular apoptosis and fibrosis in a mouse model of non-alcoholic fatty liver disease.
Telomeric DNA damage is irreparable and causes persistent DNA-damage-response activation.
A telomere-dependent DNA damage checkpoint induced by prolonged mitotic arrest.
Adeno-associated virus type 2 modulates the host DNA damage response induced by herpes simplex virus 1 during coinfection.
ATM substrate Chk2-interacting Zn2+ finger (ASCIZ) Is a bi-functional transcriptional activator and feedback sensor in the regulation of dynein light chain (DYNLL1) expression.
LEDGF (p75) promotes DNA-end resection and homologous recombination.
TRIP12 and UBR5 suppress spreading of chromatin ubiquitylation at damaged chromosomes.
Nuclear accumulation of the papillomavirus E1 helicase blocks S-phase progression and triggers an ATM-dependent DNA damage response.
DNA damage response is suppressed by the high cyclin-dependent kinase 1 activity in mitotic mammalian cells.
Chromatin remodeler sucrose nonfermenting 2 homolog (SNF2H) is recruited onto DNA replication origins through interaction with Cdc10 protein-dependent transcript 1 (Cdt1) and promotes pre-replication complex formation.
Protein-protein interactions occur between p53 phosphoforms and ATM and 53BP1 at sites of exogenous DNA damage.
Creating localized DNA double-strand breaks with microirradiation.
EDD inhibits ATM-mediated phosphorylation of p53.
The chromatin-remodeling factor CHD4 coordinates signaling and repair after DNA damage.
A genetic screen identifies the Triple T complex required for DNA damage signaling and ATM and ATR stability.
γ-H2AX and phosphorylated ATM focus formation in cancer cells after laser plasma X irradiation.
Parvovirus minute virus of mice induces a DNA damage response that facilitates viral replication.
Dual functions of ASCIZ in the DNA base damage response and pulmonary organogenesis.
A novel type of cellular senescence that can be enhanced in mouse models and human tumor xenografts to suppress prostate tumorigenesis.
The matricellular protein CCN1 induces fibroblast senescence and restricts fibrosis in cutaneous wound healing.
Multiple DNA damage signaling and repair pathways deregulated by simian virus 40 large T antigen.
Limited role of murine ATM in oncogene-induced senescence and p53-dependent tumor suppression.
Adeno-associated virus and adenovirus coinfection induces a cellular DNA damage and repair response via redundant phosphatidylinositol 3-like kinase pathways.
Redundant and differential regulation of multiple licensing factors ensures prevention of re-replication in normal human cells.
Identification of novel human Cdt1-binding proteins by a proteomics approach: proteolytic regulation by APC/CCdh1.
Chemokine signaling via the CXCR2 receptor reinforces senescence.
Tip60 is a haplo-insufficient tumour suppressor required for an oncogene-induced DNA damage response.
Proteasome function is required for DNA damage response and fanconi anemia pathway activation.
Prevention of aneuploidy by S-adenosyl-methionine in human cells treated with sodium arsenite.
ATM promotes apoptosis and suppresses tumorigenesis in response to Myc.
Conserved modes of recruitment of ATM, ATR and DNA-PKcs to sites of DNA damage.
ATM activation in normal human tissues and testicular cancer.
Melanoma cells express elevated levels of phosphorylated histone H2AX foci.
DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis.
Phosphorylation of SMC1 is a critical downstream event in the ATM-NBS1-BRCA1 pathway.
E2F1 uses the ATM signaling pathway to induce p53 and Chk2 phosphorylation and apoptosis.
DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation.
Montales K, Ruis K, Lindsay H, Michael WM
PloS one 2022;17(8):e0271905
PloS one 2022;17(8):e0271905
Chemotherapy of HER2- and MDM2-Enriched Breast Cancer Subtypes Induces Homologous Recombination DNA Repair and Chemoresistance.
Herok M, Wawrzynow B, Maluszek MJ, Olszewski MB, Zylicz A, Zylicz M
Cancers 2021 Sep 7;13(18)
Cancers 2021 Sep 7;13(18)
Class 1 Histone Deacetylases and Ataxia-Telangiectasia Mutated Kinase Control the Survival of Murine Pancreatic Cancer Cells upon dNTP Depletion.
Nguyen A, Dzulko M, Murr J, Yen Y, Schneider G, Krämer OH
Cells 2021 Sep 23;10(10)
Cells 2021 Sep 23;10(10)
HMGB1 signaling phosphorylates Ku70 and impairs DNA damage repair in Alzheimer's disease pathology.
Tanaka H, Kondo K, Fujita K, Homma H, Tagawa K, Jin X, Jin M, Yoshioka Y, Takayama S, Masuda H, Tokuyama R, Nakazaki Y, Saito T, Saido T, Murayama S, Ikura T, Ito N, Yamamori Y, Tomii K, Bianchi ME, Okazawa H
Communications biology 2021 Oct 11;4(1):1175
Communications biology 2021 Oct 11;4(1):1175
Inhibition of DNA replication initiation by silver nanoclusters.
Tao Y, Aparicio T, Li M, Leong KW, Zha S, Gautier J
Nucleic acids research 2021 May 21;49(9):5074-5083
Nucleic acids research 2021 May 21;49(9):5074-5083
DROSHA is recruited to DNA damage sites by the MRN complex to promote non-homologous end joining.
Cabrini M, Roncador M, Galbiati A, Cipolla L, Maffia A, Iannelli F, Sabbioneda S, d'Adda di Fagagna F, Francia S
Journal of cell science 2021 Mar 22;134(6)
Journal of cell science 2021 Mar 22;134(6)
DNA damage in embryonic neural stem cell determines FTLDs' fate via early-stage neuronal necrosis.
Homma H, Tanaka H, Jin M, Jin X, Huang Y, Yoshioka Y, Bertens CJ, Tsumaki K, Kondo K, Shiwaku H, Tagawa K, Akatsu H, Atsuta N, Katsuno M, Furukawa K, Ishiki A, Waragai M, Ohtomo G, Iwata A, Yokota T, Inoue H, Arai H, Sobue G, Sone M, Fujita K, Okazawa H
Life science alliance 2021 Jul;4(7)
Life science alliance 2021 Jul;4(7)
SLX4-XPF mediates DNA damage responses to replication stress induced by DNA-protein interactions.
Ishimoto R, Tsuzuki Y, Matsumura T, Kurashige S, Enokitani K, Narimatsu K, Higa M, Sugimoto N, Yoshida K, Fujita M
The Journal of cell biology 2021 Jan 4;220(1)
The Journal of cell biology 2021 Jan 4;220(1)
Structure-function analysis of TOPBP1's role in ATR signaling using the DSB-mediated ATR activation in Xenopus egg extracts (DMAX) system.
Montales K, Kim A, Ruis K, Michael WM
Scientific reports 2021 Jan 11;11(1):467
Scientific reports 2021 Jan 11;11(1):467
IFI16 inhibits DNA repair that potentiates type-I interferon-induced antitumor effects in triple negative breast cancer.
Ka NL, Lim GY, Hwang S, Kim SS, Lee MO
Cell reports 2021 Dec 21;37(12):110138
Cell reports 2021 Dec 21;37(12):110138
Evading immune surveillance via tyrosine phosphorylation of nuclear PCNA.
Wang YL, Lee CC, Shen YC, Lin PL, Wu WR, Lin YZ, Cheng WC, Chang H, Hung Y, Cho YC, Liu LC, Xia WY, Ji JH, Liang JA, Chiang SF, Liu CG, Yao J, Hung MC, Wang SC
Cell reports 2021 Aug 24;36(8):109537
Cell reports 2021 Aug 24;36(8):109537
Pb induced mitochondrial fission of fibroblast cells via ATM activation.
Qi Y, Ma L, Naeem S, Gu X, Chao X, Yuan C, Huang D
Journal of hazardous materials 2021 Aug 15;416:126177
Journal of hazardous materials 2021 Aug 15;416:126177
Keap1 inhibition sensitizes head and neck squamous cell carcinoma cells to ionizing radiation via impaired non-homologous end joining and induced autophagy.
Deville SS, Luft S, Kaufmann M, Cordes N
Cell death & disease 2020 Oct 21;11(10):887
Cell death & disease 2020 Oct 21;11(10):887
ATM Inhibitor Suppresses Gemcitabine-Resistant BTC Growth in a Polymerase θ Deficiency-Dependent Manner.
Pan YR, Wu CE, Yeh CN
Biomolecules 2020 Nov 9;10(11)
Biomolecules 2020 Nov 9;10(11)
ATM is a key driver of NF-κB-dependent DNA-damage-induced senescence, stem cell dysfunction and aging.
Zhao J, Zhang L, Lu A, Han Y, Colangelo D, Bukata C, Scibetta A, Yousefzadeh MJ, Li X, Gurkar AU, McGowan SJ, Angelini L, O'Kelly R, Li H, Corbo L, Sano T, Nick H, Pola E, Pilla SPS, Ladiges WC, Vo N, Huard J, Niedernhofer LJ, Robbins PD
Aging 2020 Mar 22;12(6):4688-4710
Aging 2020 Mar 22;12(6):4688-4710
Phospho-Ser(784)-VCP Is Required for DNA Damage Response and Is Associated with Poor Prognosis of Chemotherapy-Treated Breast Cancer.
Zhu C, Rogers A, Asleh K, Won J, Gao D, Leung S, Li S, Vij KR, Zhu J, Held JM, You Z, Nielsen TO, Shao J
Cell reports 2020 Jun 9;31(10):107745
Cell reports 2020 Jun 9;31(10):107745
Dianhydrogalactitol synergizes with topoisomerase poisons to overcome DNA repair activity in tumor cells.
Zhai B, Li Y, Kotapalli SS, Bacha J, Brown D, Steinø A, Daugaard M
Cell death & disease 2020 Jul 24;11(7):577
Cell death & disease 2020 Jul 24;11(7):577
Panobinostat and venetoclax enhance the cytotoxicity of gemcitabine, busulfan, and melphalan in multiple myeloma cells.
Valdez BC, Li Y, Murray D, Liu Y, Nieto Y, Bashir Q, Qazilbash MH, Andersson BS
Experimental hematology 2020 Jan;81:32-41
Experimental hematology 2020 Jan;81:32-41
FBXW7 Confers Radiation Survival by Targeting p53 for Degradation.
Cui D, Xiong X, Shu J, Dai X, Sun Y, Zhao Y
Cell reports 2020 Jan 14;30(2):497-509.e4
Cell reports 2020 Jan 14;30(2):497-509.e4
Association of glomerular DNA damage and DNA methylation with one-year eGFR decline in IgA nephropathy.
Hayashi K, Hishikawa A, Hashiguchi A, Azegami T, Yoshimoto N, Nakamichi R, Tokuyama H, Itoh H
Scientific reports 2020 Jan 14;10(1):237
Scientific reports 2020 Jan 14;10(1):237
SCF(β-TrCP)-mediated degradation of TOP2β promotes cancer cell survival in response to chemotherapeutic drugs targeting topoisomerase II.
Shu J, Cui D, Ma Y, Xiong X, Sun Y, Zhao Y
Oncogenesis 2020 Feb 3;9(2):8
Oncogenesis 2020 Feb 3;9(2):8
Targeting DNA-dependent protein kinase sensitizes hepatocellular carcinoma cells to proton beam irradiation through apoptosis induction.
Choi C, Son A, Lee GH, Shin SW, Park S, Ahn SH, Chung Y, Yu JI, Park HC
PloS one 2019;14(6):e0218049
PloS one 2019;14(6):e0218049
ATM controls DNA repair and mitochondria transfer between neighboring cells.
Jin S, Cordes N
Cell communication and signaling : CCS 2019 Nov 8;17(1):144
Cell communication and signaling : CCS 2019 Nov 8;17(1):144
Assessment of epigenetic mechanisms and DNA double-strand break repair using laser micro-irradiation technique developed for hematological cells.
Johnson DP, Spitz-Becker GS, Chakraborti K, Bhaskara S
EBioMedicine 2019 May;43:138-149
EBioMedicine 2019 May;43:138-149
ATM phosphorylation of the actin-binding protein drebrin controls oxidation stress-resistance in mammalian neurons and C. elegans.
Kreis P, Gallrein C, Rojas-Puente E, Mack TGA, Kroon C, Dinkel V, Willmes C, Murk K, Tom-Dieck S, Schuman EM, Kirstein J, Eickholt BJ
Nature communications 2019 Jan 30;10(1):486
Nature communications 2019 Jan 30;10(1):486
PPARγ Interaction with UBR5/ATMIN Promotes DNA Repair to Maintain Endothelial Homeostasis.
Li CG, Mahon C, Sweeney NM, Verschueren E, Kantamani V, Li D, Hennigs JK, Marciano DP, Diebold I, Abu-Halawa O, Elliott M, Sa S, Guo F, Wang L, Cao A, Guignabert C, Sollier J, Nickel NP, Kaschwich M, Cimprich KA, Rabinovitch M
Cell reports 2019 Jan 29;26(5):1333-1343.e7
Cell reports 2019 Jan 29;26(5):1333-1343.e7
CSB promoter downregulation via histone H3 hypoacetylation is an early determinant of replicative senescence.
Crochemore C, Fernández-Molina C, Montagne B, Salles A, Ricchetti M
Nature communications 2019 Dec 6;10(1):5576
Nature communications 2019 Dec 6;10(1):5576
Cell-based chemical fingerprinting identifies telomeres and lamin A as modifiers of DNA damage response in cancer cells.
Fujiwara C, Muramatsu Y, Nishii M, Tokunaka K, Tahara H, Ueno M, Yamori T, Sugimoto Y, Seimiya H
Scientific reports 2018 Oct 4;8(1):14827
Scientific reports 2018 Oct 4;8(1):14827
Dianhydrogalactitol induces replication-dependent DNA damage in tumor cells preferentially resolved by homologous recombination.
Zhai B, Steinø A, Bacha J, Brown D, Daugaard M
Cell death & disease 2018 Oct 3;9(10):1016
Cell death & disease 2018 Oct 3;9(10):1016
Transcription and mRNA export machineries SAGA and TREX-2 maintain monoubiquitinated H2B balance required for DNA repair.
Evangelista FM, Maglott-Roth A, Stierle M, Brino L, Soutoglou E, Tora L
The Journal of cell biology 2018 Oct 1;217(10):3382-3397
The Journal of cell biology 2018 Oct 1;217(10):3382-3397
Epigenetic modification enhances the cytotoxicity of busulfan and4-hydroperoxycyclophosphamide in AML cells.
Valdez BC, Tang X, Li Y, Murray D, Liu Y, Popat U, Champlin RE, Andersson BS
Experimental hematology 2018 Nov;67:49-59.e1
Experimental hematology 2018 Nov;67:49-59.e1
Distinct roles of ATM and ATR in the regulation of ARP8 phosphorylation to prevent chromosome translocations.
Sun J, Shi L, Kinomura A, Fukuto A, Horikoshi Y, Oma Y, Harata M, Ikura M, Ikura T, Kanaar R, Tashiro S
eLife 2018 May 8;7
eLife 2018 May 8;7
DNA Repair Network Analysis Reveals Shieldin as a Key Regulator of NHEJ and PARP Inhibitor Sensitivity.
Gupta R, Somyajit K, Narita T, Maskey E, Stanlie A, Kremer M, Typas D, Lammers M, Mailand N, Nussenzweig A, Lukas J, Choudhary C
Cell 2018 May 3;173(4):972-988.e23
Cell 2018 May 3;173(4):972-988.e23
PTEN deletion in luminal cells of mature prostate induces replication stress and senescence in vivo.
Parisotto M, Grelet E, El Bizri R, Dai Y, Terzic J, Eckert D, Gargowitsch L, Bornert JM, Metzger D
The Journal of experimental medicine 2018 Jun 4;215(6):1749-1763
The Journal of experimental medicine 2018 Jun 4;215(6):1749-1763
Lead (Pb) induced ATM-dependent mitophagy via PINK1/Parkin pathway.
Gu X, Qi Y, Feng Z, Ma L, Gao K, Zhang Y
Toxicology letters 2018 Jul;291:92-100
Toxicology letters 2018 Jul;291:92-100
HDAC1 and HDAC2 integrate checkpoint kinase phosphorylation and cell fate through the phosphatase-2A subunit PR130.
Göder A, Emmerich C, Nikolova T, Kiweler N, Schreiber M, Kühl T, Imhof D, Christmann M, Heinzel T, Schneider G, Krämer OH
Nature communications 2018 Feb 22;9(1):764
Nature communications 2018 Feb 22;9(1):764
The Augmented R-Loop Is a Unifying Mechanism for Myelodysplastic Syndromes Induced by High-Risk Splicing Factor Mutations.
Chen L, Chen JY, Huang YJ, Gu Y, Qiu J, Qian H, Shao C, Zhang X, Hu J, Li H, He S, Zhou Y, Abdel-Wahab O, Zhang DE, Fu XD
Molecular cell 2018 Feb 1;69(3):412-425.e6
Molecular cell 2018 Feb 1;69(3):412-425.e6
GFI1 facilitates efficient DNA repair by regulating PRMT1 dependent methylation of MRE11 and 53BP1.
Vadnais C, Chen R, Fraszczak J, Yu Z, Boulais J, Pinder J, Frank D, Khandanpour C, Hébert J, Dellaire G, Côté JF, Richard S, Orthwein A, Drobetsky E, Möröy T
Nature communications 2018 Apr 12;9(1):1418
Nature communications 2018 Apr 12;9(1):1418
BRCA2 suppresses replication stress-induced mitotic and G1 abnormalities through homologous recombination.
Feng W, Jasin M
Nature communications 2017 Sep 13;8(1):525
Nature communications 2017 Sep 13;8(1):525
The PARP inhibitor olaparib enhances the cytotoxicity of combined gemcitabine, busulfan and melphalan in lymphoma cells.
Valdez BC, Li Y, Murray D, Liu Y, Nieto Y, Champlin RE, Andersson BS
Leukemia & lymphoma 2017 Nov;58(11):2705-2716
Leukemia & lymphoma 2017 Nov;58(11):2705-2716
LRRK2 interacts with ATM and regulates Mdm2-p53 cell proliferation axis in response to genotoxic stress.
Chen Z, Cao Z, Zhang W, Gu M, Zhou ZD, Li B, Li J, Tan EK, Zeng L
Human molecular genetics 2017 Nov 15;26(22):4494-4505
Human molecular genetics 2017 Nov 15;26(22):4494-4505
Coumarin-chalcone hybrid instigates DNA damage by minor groove binding and stabilizes p53 through post translational modifications.
Ashraf R, Hamidullah, Hasanain M, Pandey P, Maheshwari M, Singh LR, Siddiqui MQ, Konwar R, Sashidhara KV, Sarkar J
Scientific reports 2017 Mar 28;7:45287
Scientific reports 2017 Mar 28;7:45287
Oridonin promotes G2/M arrest in A549 cells by facilitating ATM activation.
Zheng M, Zhu Z, Zhao Y, Yao D, Wu M, Sun G
Molecular medicine reports 2017 Jan;15(1):375-379
Molecular medicine reports 2017 Jan;15(1):375-379
Damage-induced lncRNAs control the DNA damage response through interaction with DDRNAs at individual double-strand breaks.
Michelini F, Pitchiaya S, Vitelli V, Sharma S, Gioia U, Pessina F, Cabrini M, Wang Y, Capozzo I, Iannelli F, Matti V, Francia S, Shivashankar GV, Walter NG, d'Adda di Fagagna F
Nature cell biology 2017 Dec;19(12):1400-1411
Nature cell biology 2017 Dec;19(12):1400-1411
DNA single-strand break-induced DNA damage response causes heart failure.
Higo T, Naito AT, Sumida T, Shibamoto M, Okada K, Nomura S, Nakagawa A, Yamaguchi T, Sakai T, Hashimoto A, Kuramoto Y, Ito M, Hikoso S, Akazawa H, Lee JK, Shiojima I, McKinnon PJ, Sakata Y, Komuro I
Nature communications 2017 Apr 24;8:15104
Nature communications 2017 Apr 24;8:15104
Epigenetic therapy with inhibitors of histone methylation suppresses DNA damage signaling and increases glioma cell radiosensitivity.
Gursoy-Yuzugullu O, Carman C, Serafim RB, Myronakis M, Valente V, Price BD
Oncotarget 2017 Apr 11;8(15):24518-24532
Oncotarget 2017 Apr 11;8(15):24518-24532
Impaired 53BP1/RIF1 DSB mediated end-protection stimulates CtIP-dependent end resection and switches the repair to PARP1-dependent end joining in G1.
Bakr A, Köcher S, Volquardsen J, Petersen C, Borgmann K, Dikomey E, Rothkamm K, Mansour WY
Oncotarget 2016 Sep 6;7(36):57679-57693
Oncotarget 2016 Sep 6;7(36):57679-57693
UV-dependent phosphorylation of COP9/signalosome in UV-induced apoptosis.
Dubois EL, Gerber S, Kisselev A, Harel-Bellan A, Groisman R
Oncology reports 2016 May;35(5):3101-5
Oncology reports 2016 May;35(5):3101-5
Redox regulation of SUMO enzymes is required for ATM activity and survival in oxidative stress.
Stankovic-Valentin N, Drzewicka K, König C, Schiebel E, Melchior F
The EMBO journal 2016 Jun 15;35(12):1312-29
The EMBO journal 2016 Jun 15;35(12):1312-29
SCAI promotes DNA double-strand break repair in distinct chromosomal contexts.
Hansen RK, Mund A, Poulsen SL, Sandoval M, Klement K, Tsouroula K, Tollenaere MA, Räschle M, Soria R, Offermanns S, Worzfeld T, Grosse R, Brandt DT, Rozell B, Mann M, Cole F, Soutoglou E, Goodarzi AA, Daniel JA, Mailand N, Bekker-Jensen S
Nature cell biology 2016 Dec;18(12):1357-1366
Nature cell biology 2016 Dec;18(12):1357-1366
Mutant IDH1 Downregulates ATM and Alters DNA Repair and Sensitivity to DNA Damage Independent of TET2.
Inoue S, Li WY, Tseng A, Beerman I, Elia AJ, Bendall SC, Lemonnier F, Kron KJ, Cescon DW, Hao Z, Lind EF, Takayama N, Planello AC, Shen SY, Shih AH, Larsen DM, Li Q, Snow BE, Wakeham A, Haight J, Gorrini C, Bassi C, Thu KL, Murakami K, Elford AR, Ueda T, Straley K, Yen KE, Melino G, Cimmino L, Aifantis I, Levine RL, De Carvalho DD, Lupien M, Rossi DJ, Nolan GP, Cairns RA, Mak TW
Cancer cell 2016 Aug 8;30(2):337-348
Cancer cell 2016 Aug 8;30(2):337-348
ATM mediates spermidine-induced mitophagy via PINK1 and Parkin regulation in human fibroblasts.
Qi Y, Qiu Q, Gu X, Tian Y, Zhang Y
Scientific reports 2016 Apr 19;6:24700
Scientific reports 2016 Apr 19;6:24700
DNA Damage Signaling Is Induced in the Absence of Epstein-Barr Virus (EBV) Lytic DNA Replication and in Response to Expression of ZEBRA.
Wang'ondu R, Teal S, Park R, Heston L, Delecluse H, Miller G
PloS one 2015;10(5):e0126088
PloS one 2015;10(5):e0126088
Recruitment and activation of the ATM kinase in the absence of DNA-damage sensors.
Hartlerode AJ, Morgan MJ, Wu Y, Buis J, Ferguson DO
Nature structural & molecular biology 2015 Sep;22(9):736-43
Nature structural & molecular biology 2015 Sep;22(9):736-43
Role of the Exocyst Complex Component Sec6/8 in Genomic Stability.
Torres MJ, Pandita RK, Kulak O, Kumar R, Formstecher E, Horikoshi N, Mujoo K, Hunt CR, Zhao Y, Lum L, Zaman A, Yeaman C, White MA, Pandita TK
Molecular and cellular biology 2015 Nov;35(21):3633-45
Molecular and cellular biology 2015 Nov;35(21):3633-45
Notch is a direct negative regulator of the DNA-damage response.
Vermezovic J, Adamowicz M, Santarpia L, Rustighi A, Forcato M, Lucano C, Massimiliano L, Costanzo V, Bicciato S, Del Sal G, d'Adda di Fagagna F
Nature structural & molecular biology 2015 May;22(5):417-24
Nature structural & molecular biology 2015 May;22(5):417-24
Stemness factor Sall4 is required for DNA damage response in embryonic stem cells.
Xiong J, Todorova D, Su NY, Kim J, Lee PJ, Shen Z, Briggs SP, Xu Y
The Journal of cell biology 2015 Mar 2;208(5):513-20
The Journal of cell biology 2015 Mar 2;208(5):513-20
CDK1 inhibition targets the p53-NOXA-MCL1 axis, selectively kills embryonic stem cells, and prevents teratoma formation.
Huskey NE, Guo T, Evason KJ, Momcilovic O, Pardo D, Creasman KJ, Judson RL, Blelloch R, Oakes SA, Hebrok M, Goga A
Stem cell reports 2015 Mar 10;4(3):374-89
Stem cell reports 2015 Mar 10;4(3):374-89
Comparison of the cytotoxicity of cladribine and clofarabine when combined with fludarabine and busulfan in AML cells: Enhancement of cytotoxicity with epigenetic modulators.
Valdez BC, Li Y, Murray D, Ji J, Liu Y, Popat U, Champlin RE, Andersson BS
Experimental hematology 2015 Jun;43(6):448-61.e2
Experimental hematology 2015 Jun;43(6):448-61.e2
Dgcr8 and Dicer are essential for sex chromosome integrity during meiosis in males.
Modzelewski AJ, Hilz S, Crate EA, Schweidenback CT, Fogarty EA, Grenier JK, Freire R, Cohen PE, Grimson A
Journal of cell science 2015 Jun 15;128(12):2314-27
Journal of cell science 2015 Jun 15;128(12):2314-27
The complexity of DNA double strand break is a crucial factor for activating ATR signaling pathway for G2/M checkpoint regulation regardless of ATM function.
Xue L, Furusawa Y, Okayasu R, Miura M, Cui X, Liu C, Hirayama R, Matsumoto Y, Yajima H, Yu D
DNA repair 2015 Jan;25:72-83
DNA repair 2015 Jan;25:72-83
Murine Gammaherpesvirus 68 LANA and SOX Homologs Counteract ATM-Driven p53 Activity during Lytic Viral Replication.
Sifford JM, Stahl JA, Salinas E, Forrest JC
Journal of virology 2015 Dec 16;90(5):2571-85
Journal of virology 2015 Dec 16;90(5):2571-85
Expression of the genetic suppressor element 24.2 (GSE24.2) decreases DNA damage and oxidative stress in X-linked dyskeratosis congenita cells.
Manguan-Garcia C, Pintado-Berninches L, Carrillo J, Machado-Pinilla R, Sastre L, Pérez-Quilis C, Esmoris I, Gimeno A, García-Giménez JL, Pallardó FV, Perona R
PloS one 2014;9(7):e101424
PloS one 2014;9(7):e101424
Stable cellular senescence is associated with persistent DDR activation.
Fumagalli M, Rossiello F, Mondello C, d'Adda di Fagagna F
PloS one 2014;9(10):e110969
PloS one 2014;9(10):e110969
A separable domain of the p150 subunit of human chromatin assembly factor-1 promotes protein and chromosome associations with nucleoli.
Smith CL, Matheson TD, Trombly DJ, Sun X, Campeau E, Han X, Yates JR 3rd, Kaufman PD
Molecular biology of the cell 2014 Sep 15;25(18):2866-81
Molecular biology of the cell 2014 Sep 15;25(18):2866-81
SETD2 is required for DNA double-strand break repair and activation of the p53-mediated checkpoint.
Carvalho S, Vítor AC, Sridhara SC, Martins FB, Raposo AC, Desterro JM, Ferreira J, de Almeida SF
eLife 2014 May 6;3:e02482
eLife 2014 May 6;3:e02482
BRCA1 establishes DNA damage signaling and pericentric heterochromatin of the X chromosome in male meiosis.
Broering TJ, Alavattam KG, Sadreyev RI, Ichijima Y, Kato Y, Hasegawa K, Camerini-Otero RD, Lee JT, Andreassen PR, Namekawa SH
The Journal of cell biology 2014 Jun 9;205(5):663-75
The Journal of cell biology 2014 Jun 9;205(5):663-75
Ribosomal S6 Kinase 2 (RSK2) maintains genomic stability by activating the Atm/p53-dependent DNA damage pathway.
Lim HC, Xie L, Zhang W, Li R, Chen ZC, Wu GZ, Cui SS, Tan EK, Zeng L
PloS one 2013;8(9):e74334
PloS one 2013;8(9):e74334
Poly(ADP-ribose) binding to Chk1 at stalled replication forks is required for S-phase checkpoint activation.
Min W, Bruhn C, Grigaravicius P, Zhou ZW, Li F, Krüger A, Siddeek B, Greulich KO, Popp O, Meisezahl C, Calkhoven CF, Bürkle A, Xu X, Wang ZQ
Nature communications 2013;4:2993
Nature communications 2013;4:2993
ATR prohibits replication catastrophe by preventing global exhaustion of RPA.
Toledo LI, Altmeyer M, Rask MB, Lukas C, Larsen DH, Povlsen LK, Bekker-Jensen S, Mailand N, Bartek J, Lukas J
Cell 2013 Nov 21;155(5):1088-103
Cell 2013 Nov 21;155(5):1088-103
Telomere crisis in kidney epithelial cells promotes the acquisition of a microRNA signature retrieved in aggressive renal cell carcinomas.
Castro-Vega LJ, Jouravleva K, Liu WY, Martinez C, Gestraud P, Hupé P, Servant N, Albaud B, Gentien D, Gad S, Richard S, Bacchetti S, Londoño-Vallejo A
Carcinogenesis 2013 May;34(5):1173-80
Carcinogenesis 2013 May;34(5):1173-80
Sodium tungstate modulates ATM function upon DNA damage.
Rodriguez-Hernandez CJ, Llorens-Agost M, Calbó J, Murguia JR, Guinovart JJ
FEBS letters 2013 May 21;587(10):1579-86
FEBS letters 2013 May 21;587(10):1579-86
Detection of impaired homologous recombination repair in NSCLC cells and tissues.
Birkelbach M, Ferraiolo N, Gheorghiu L, Pfäffle HN, Daly B, Ebright MI, Spencer C, O'Hara C, Whetstine JR, Benes CH, Sequist LV, Zou L, Dahm-Daphi J, Kachnic LA, Willers H
Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer 2013 Mar;8(3):279-86
Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer 2013 Mar;8(3):279-86
The bromodomain protein Brd4 insulates chromatin from DNA damage signalling.
Floyd SR, Pacold ME, Huang Q, Clarke SM, Lam FC, Cannell IG, Bryson BD, Rameseder J, Lee MJ, Blake EJ, Fydrych A, Ho R, Greenberger BA, Chen GC, Maffa A, Del Rosario AM, Root DE, Carpenter AE, Hahn WC, Sabatini DM, Chen CC, White FM, Bradner JE, Yaffe MB
Nature 2013 Jun 13;498(7453):246-50
Nature 2013 Jun 13;498(7453):246-50
The telomere deprotection response is functionally distinct from the genomic DNA damage response.
Cesare AJ, Hayashi MT, Crabbe L, Karlseder J
Molecular cell 2013 Jul 25;51(2):141-55
Molecular cell 2013 Jul 25;51(2):141-55
BMS-345541 sensitizes MCF-7 breast cancer cells to ionizing radiation by selective inhibition of homologous recombinational repair of DNA double-strand breaks.
Wu L, Shao L, Li M, Zheng J, Wang J, Feng W, Chang J, Wang Y, Hauer-Jensen M, Zhou D
Radiation research 2013 Feb;179(2):160-70
Radiation research 2013 Feb;179(2):160-70
ATM mediates pRB function to control DNMT1 protein stability and DNA methylation.
Shamma A, Suzuki M, Hayashi N, Kobayashi M, Sasaki N, Nishiuchi T, Doki Y, Okamoto T, Kohno S, Muranaka H, Kitajima S, Yamamoto K, Takahashi C
Molecular and cellular biology 2013 Aug;33(16):3113-24
Molecular and cellular biology 2013 Aug;33(16):3113-24
DNA structure-specific priming of ATR activation by DNA-PKcs.
Vidal-Eychenié S, Décaillet C, Basbous J, Constantinou A
The Journal of cell biology 2013 Aug 5;202(3):421-9
The Journal of cell biology 2013 Aug 5;202(3):421-9
Threonine 2609 phosphorylation of the DNA-dependent protein kinase is a critical prerequisite for epidermal growth factor receptor-mediated radiation resistance.
Javvadi P, Makino H, Das AK, Lin YF, Chen DJ, Chen BP, Nirodi CS
Molecular cancer research : MCR 2012 Oct;10(10):1359-68
Molecular cancer research : MCR 2012 Oct;10(10):1359-68
Nuclear lamina defects cause ATM-dependent NF-κB activation and link accelerated aging to a systemic inflammatory response.
Osorio FG, Bárcena C, Soria-Valles C, Ramsay AJ, de Carlos F, Cobo J, Fueyo A, Freije JM, López-Otín C
Genes & development 2012 Oct 15;26(20):2311-24
Genes & development 2012 Oct 15;26(20):2311-24
CUX1 transcription factor is required for optimal ATM/ATR-mediated responses to DNA damage.
Vadnais C, Davoudi S, Afshin M, Harada R, Dudley R, Clermont PL, Drobetsky E, Nepveu A
Nucleic acids research 2012 May;40(10):4483-95
Nucleic acids research 2012 May;40(10):4483-95
The DNA damage checkpoint protein ATM promotes hepatocellular apoptosis and fibrosis in a mouse model of non-alcoholic fatty liver disease.
Daugherity EK, Balmus G, Al Saei A, Moore ES, Abi Abdallah D, Rogers AB, Weiss RS, Maurer KJ
Cell cycle (Georgetown, Tex.) 2012 May 15;11(10):1918-28
Cell cycle (Georgetown, Tex.) 2012 May 15;11(10):1918-28
Telomeric DNA damage is irreparable and causes persistent DNA-damage-response activation.
Fumagalli M, Rossiello F, Clerici M, Barozzi S, Cittaro D, Kaplunov JM, Bucci G, Dobreva M, Matti V, Beausejour CM, Herbig U, Longhese MP, d'Adda di Fagagna F
Nature cell biology 2012 Mar 18;14(4):355-65
Nature cell biology 2012 Mar 18;14(4):355-65
A telomere-dependent DNA damage checkpoint induced by prolonged mitotic arrest.
Hayashi MT, Cesare AJ, Fitzpatrick JA, Lazzerini-Denchi E, Karlseder J
Nature structural & molecular biology 2012 Mar 11;19(4):387-94
Nature structural & molecular biology 2012 Mar 11;19(4):387-94
Adeno-associated virus type 2 modulates the host DNA damage response induced by herpes simplex virus 1 during coinfection.
Vogel R, Seyffert M, Strasser R, de Oliveira AP, Dresch C, Glauser DL, Jolinon N, Salvetti A, Weitzman MD, Ackermann M, Fraefel C
Journal of virology 2012 Jan;86(1):143-55
Journal of virology 2012 Jan;86(1):143-55
ATM substrate Chk2-interacting Zn2+ finger (ASCIZ) Is a bi-functional transcriptional activator and feedback sensor in the regulation of dynein light chain (DYNLL1) expression.
Jurado S, Conlan LA, Baker EK, Ng JL, Tenis N, Hoch NC, Gleeson K, Smeets M, Izon D, Heierhorst J
The Journal of biological chemistry 2012 Jan 27;287(5):3156-64
The Journal of biological chemistry 2012 Jan 27;287(5):3156-64
LEDGF (p75) promotes DNA-end resection and homologous recombination.
Daugaard M, Baude A, Fugger K, Povlsen LK, Beck H, Sørensen CS, Petersen NH, Sorensen PH, Lukas C, Bartek J, Lukas J, Rohde M, Jäättelä M
Nature structural & molecular biology 2012 Aug;19(8):803-10
Nature structural & molecular biology 2012 Aug;19(8):803-10
TRIP12 and UBR5 suppress spreading of chromatin ubiquitylation at damaged chromosomes.
Gudjonsson T, Altmeyer M, Savic V, Toledo L, Dinant C, Grøfte M, Bartkova J, Poulsen M, Oka Y, Bekker-Jensen S, Mailand N, Neumann B, Heriche JK, Shearer R, Saunders D, Bartek J, Lukas J, Lukas C
Cell 2012 Aug 17;150(4):697-709
Cell 2012 Aug 17;150(4):697-709
Nuclear accumulation of the papillomavirus E1 helicase blocks S-phase progression and triggers an ATM-dependent DNA damage response.
Fradet-Turcotte A, Bergeron-Labrecque F, Moody CA, Lehoux M, Laimins LA, Archambault J
Journal of virology 2011 Sep;85(17):8996-9012
Journal of virology 2011 Sep;85(17):8996-9012
DNA damage response is suppressed by the high cyclin-dependent kinase 1 activity in mitotic mammalian cells.
Zhang W, Peng G, Lin SY, Zhang P
The Journal of biological chemistry 2011 Oct 14;286(41):35899-35905
The Journal of biological chemistry 2011 Oct 14;286(41):35899-35905
Chromatin remodeler sucrose nonfermenting 2 homolog (SNF2H) is recruited onto DNA replication origins through interaction with Cdc10 protein-dependent transcript 1 (Cdt1) and promotes pre-replication complex formation.
Sugimoto N, Yugawa T, Iizuka M, Kiyono T, Fujita M
The Journal of biological chemistry 2011 Nov 11;286(45):39200-10
The Journal of biological chemistry 2011 Nov 11;286(45):39200-10
Protein-protein interactions occur between p53 phosphoforms and ATM and 53BP1 at sites of exogenous DNA damage.
Al Rashid ST, Harding SM, Law C, Coackley C, Bristow RG
Radiation research 2011 May;175(5):588-98
Radiation research 2011 May;175(5):588-98
Creating localized DNA double-strand breaks with microirradiation.
Suzuki K, Yamauchi M, Oka Y, Suzuki M, Yamashita S
Nature protocols 2011 Feb;6(2):134-9
Nature protocols 2011 Feb;6(2):134-9
EDD inhibits ATM-mediated phosphorylation of p53.
Ling S, Lin WC
The Journal of biological chemistry 2011 Apr 29;286(17):14972-82
The Journal of biological chemistry 2011 Apr 29;286(17):14972-82
The chromatin-remodeling factor CHD4 coordinates signaling and repair after DNA damage.
Larsen DH, Poinsignon C, Gudjonsson T, Dinant C, Payne MR, Hari FJ, Rendtlew Danielsen JM, Menard P, Sand JC, Stucki M, Lukas C, Bartek J, Andersen JS, Lukas J
The Journal of cell biology 2010 Sep 6;190(5):731-40
The Journal of cell biology 2010 Sep 6;190(5):731-40
A genetic screen identifies the Triple T complex required for DNA damage signaling and ATM and ATR stability.
Hurov KE, Cotta-Ramusino C, Elledge SJ
Genes & development 2010 Sep 1;24(17):1939-50
Genes & development 2010 Sep 1;24(17):1939-50
γ-H2AX and phosphorylated ATM focus formation in cancer cells after laser plasma X irradiation.
Sato K, Nishikino M, Okano Y, Ohshima S, Hasegawa N, Ishino M, Kawachi T, Numasaki H, Teshima T, Nishimura H
Radiation research 2010 Oct;174(4):436-45
Radiation research 2010 Oct;174(4):436-45
Parvovirus minute virus of mice induces a DNA damage response that facilitates viral replication.
Adeyemi RO, Landry S, Davis ME, Weitzman MD, Pintel DJ
PLoS pathogens 2010 Oct 7;6(10):e1001141
PLoS pathogens 2010 Oct 7;6(10):e1001141
Dual functions of ASCIZ in the DNA base damage response and pulmonary organogenesis.
Jurado S, Smyth I, van Denderen B, Tenis N, Hammet A, Hewitt K, Ng JL, McNees CJ, Kozlov SV, Oka H, Kobayashi M, Conlan LA, Cole TJ, Yamamoto K, Taniguchi Y, Takeda S, Lavin MF, Heierhorst J
PLoS genetics 2010 Oct 21;6(10):e1001170
PLoS genetics 2010 Oct 21;6(10):e1001170
A novel type of cellular senescence that can be enhanced in mouse models and human tumor xenografts to suppress prostate tumorigenesis.
Alimonti A, Nardella C, Chen Z, Clohessy JG, Carracedo A, Trotman LC, Cheng K, Varmeh S, Kozma SC, Thomas G, Rosivatz E, Woscholski R, Cognetti F, Scher HI, Pandolfi PP
The Journal of clinical investigation 2010 Mar;120(3):681-93
The Journal of clinical investigation 2010 Mar;120(3):681-93
The matricellular protein CCN1 induces fibroblast senescence and restricts fibrosis in cutaneous wound healing.
Jun JI, Lau LF
Nature cell biology 2010 Jul;12(7):676-85
Nature cell biology 2010 Jul;12(7):676-85
Multiple DNA damage signaling and repair pathways deregulated by simian virus 40 large T antigen.
Boichuk S, Hu L, Hein J, Gjoerup OV
Journal of virology 2010 Aug;84(16):8007-20
Journal of virology 2010 Aug;84(16):8007-20
Limited role of murine ATM in oncogene-induced senescence and p53-dependent tumor suppression.
Efeyan A, Murga M, Martinez-Pastor B, Ortega-Molina A, Soria R, Collado M, Fernandez-Capetillo O, Serrano M
PloS one 2009;4(5):e5475
PloS one 2009;4(5):e5475
Adeno-associated virus and adenovirus coinfection induces a cellular DNA damage and repair response via redundant phosphatidylinositol 3-like kinase pathways.
Collaco RF, Bevington JM, Bhrigu V, Kalman-Maltese V, Trempe JP
Virology 2009 Sep 15;392(1):24-33
Virology 2009 Sep 15;392(1):24-33
Redundant and differential regulation of multiple licensing factors ensures prevention of re-replication in normal human cells.
Sugimoto N, Yoshida K, Tatsumi Y, Yugawa T, Narisawa-Saito M, Waga S, Kiyono T, Fujita M
Journal of cell science 2009 Apr 15;122(Pt 8):1184-91
Journal of cell science 2009 Apr 15;122(Pt 8):1184-91
Identification of novel human Cdt1-binding proteins by a proteomics approach: proteolytic regulation by APC/CCdh1.
Sugimoto N, Kitabayashi I, Osano S, Tatsumi Y, Yugawa T, Narisawa-Saito M, Matsukage A, Kiyono T, Fujita M
Molecular biology of the cell 2008 Mar;19(3):1007-21
Molecular biology of the cell 2008 Mar;19(3):1007-21
Chemokine signaling via the CXCR2 receptor reinforces senescence.
Acosta JC, O'Loghlen A, Banito A, Guijarro MV, Augert A, Raguz S, Fumagalli M, Da Costa M, Brown C, Popov N, Takatsu Y, Melamed J, d'Adda di Fagagna F, Bernard D, Hernando E, Gil J
Cell 2008 Jun 13;133(6):1006-18
Cell 2008 Jun 13;133(6):1006-18
Tip60 is a haplo-insufficient tumour suppressor required for an oncogene-induced DNA damage response.
Gorrini C, Squatrito M, Luise C, Syed N, Perna D, Wark L, Martinato F, Sardella D, Verrecchia A, Bennett S, Confalonieri S, Cesaroni M, Marchesi F, Gasco M, Scanziani E, Capra M, Mai S, Nuciforo P, Crook T, Lough J, Amati B
Nature 2007 Aug 30;448(7157):1063-7
Nature 2007 Aug 30;448(7157):1063-7
Proteasome function is required for DNA damage response and fanconi anemia pathway activation.
Jacquemont C, Taniguchi T
Cancer research 2007 Aug 1;67(15):7395-405
Cancer research 2007 Aug 1;67(15):7395-405
Prevention of aneuploidy by S-adenosyl-methionine in human cells treated with sodium arsenite.
Ramírez T, Stopper H, Hock R, Herrera LA
Mutation research 2007 Apr 1;617(1-2):16-22
Mutation research 2007 Apr 1;617(1-2):16-22
ATM promotes apoptosis and suppresses tumorigenesis in response to Myc.
Pusapati RV, Rounbehler RJ, Hong S, Powers JT, Yan M, Kiguchi K, McArthur MJ, Wong PK, Johnson DG
Proceedings of the National Academy of Sciences of the United States of America 2006 Jan 31;103(5):1446-51
Proceedings of the National Academy of Sciences of the United States of America 2006 Jan 31;103(5):1446-51
Conserved modes of recruitment of ATM, ATR and DNA-PKcs to sites of DNA damage.
Falck J, Coates J, Jackson SP
Nature 2005 Mar 31;434(7033):605-11
Nature 2005 Mar 31;434(7033):605-11
ATM activation in normal human tissues and testicular cancer.
Bartkova J, Bakkenist CJ, Rajpert-De Meyts E, Skakkebaek NE, Sehested M, Lukas J, Kastan MB, Bartek J
Cell cycle (Georgetown, Tex.) 2005 Jun;4(6):838-45
Cell cycle (Georgetown, Tex.) 2005 Jun;4(6):838-45
Melanoma cells express elevated levels of phosphorylated histone H2AX foci.
Warters RL, Adamson PJ, Pond CD, Leachman SA
The Journal of investigative dermatology 2005 Apr;124(4):807-17
The Journal of investigative dermatology 2005 Apr;124(4):807-17
DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis.
Bartkova J, Horejsí Z, Koed K, Krämer A, Tort F, Zieger K, Guldberg P, Sehested M, Nesland JM, Lukas C, Ørntoft T, Lukas J, Bartek J
Nature 2005 Apr 14;434(7035):864-70
Nature 2005 Apr 14;434(7035):864-70
Phosphorylation of SMC1 is a critical downstream event in the ATM-NBS1-BRCA1 pathway.
Kitagawa R, Bakkenist CJ, McKinnon PJ, Kastan MB
Genes & development 2004 Jun 15;18(12):1423-38
Genes & development 2004 Jun 15;18(12):1423-38
E2F1 uses the ATM signaling pathway to induce p53 and Chk2 phosphorylation and apoptosis.
Powers JT, Hong S, Mayhew CN, Rogers PM, Knudsen ES, Johnson DG
Molecular cancer research : MCR 2004 Apr;2(4):203-14
Molecular cancer research : MCR 2004 Apr;2(4):203-14
DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation.
Bakkenist CJ, Kastan MB
Nature 2003 Jan 30;421(6922):499-506
Nature 2003 Jan 30;421(6922):499-506
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