ARHGAP4

This gene encodes a member of the rhoGAP family of proteins which play a role in the regulation of small GTP-binding proteins belonging to the RAS superfamily. The protein encoded by the orthologous gene in rat is localized to the Golgi complex and can redistribute to microtubules. The rat protein stimulates the activity of some Rho GTPases in vitro. Genomic deletions of this gene and a neighboring gene have been found in patients with nephrogenic diabetes insipidus. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]

Description

Rho GTPase activating protein 4

Tissue specificity

Tissue enhanced (bone marrow, lymphoid tissue)

Subcell location

Cytosol

Predicted location

Intracellular

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

X (153907367 - 153934999)

Ensembl ID

ENSG00000089820  (ver. 103.38)

Orthologs

Mouse Arhgap4: ENSMUSG00000031389

UniProt

P98171

neXtProt

NX_P98171

Human splice variants
Mouse splice variants

Protein structure