BCL3

This gene is a proto-oncogene candidate. It is identified by its translocation into the immunoglobulin alpha-locus in some cases of B-cell leukemia. The protein encoded by this gene contains seven ankyrin repeats, which are most closely related to those found in I kappa B proteins. This protein functions as a transcriptional co-activator that activates through its association with NF-kappa B homodimers. The expression of this gene can be induced by NF-kappa B, which forms a part of the autoregulatory loop that controls the nuclear residence of p50 NF-kappa B. [provided by RefSeq, Jul 2008]

Description

BCL3 transcription coactivator

Protein family

Cancer-related genes, Disease related genes, Mapped to neXtProt, Mapped to UniProt SWISS-PROT, Plasma proteins, Predicted intracellular proteins, Protein evidence (Peptideatlas), Transcription factors

Chromosome

19:q13.32 (44747705 - 44760044)

Ensembl ID

ENSG00000069399  (ver. 99.38)

Orthologs

Mouse Bcl3: ENSMUSG00000053175

UniProt

P20749

neXtProt

NX_P20749

Human splice variants
Mouse splice variants