TNFSF10

gene product
Apo-2L, CD253, TL2, TRAIL
The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein preferentially induces apoptosis in transformed and tumor cells, but does not appear to kill normal cells although it is expressed at a significant level in most normal tissues. This protein binds to several members of TNF receptor superfamily including TNFRSF10A/TRAILR1, TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4, and possibly also to TNFRSF11B/OPG. The activity of this protein may be modulated by binding to the decoy receptors TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4, and TNFRSF11B/OPG that cannot induce apoptosis. The binding of this protein to its receptors has been shown to trigger the activation of MAPK8/JNK, caspase 8, and caspase 3. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2010]
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Novus Biologicals
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13 antibodies
Enzo Life Sciences
8 antibodies
Cell Signaling Technology, Inc
2 antibodies
antibodies-online
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Invitrogen Antibodies
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Bioworld Technology, Inc
3 antibodies
Arigo
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SignalChem
1 antibody
ReliaTech GmbH
2 antibodies
Atlas Antibodies
1 antibody
Abbkine Scientific Co.Ltd.
2 antibodies
Proteintech Group
1 antibody
Creative Biolabs
49 antibodies
ProSci
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St John's Laboratory
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Abgent
5 antibodies
NSJ Bioreagents
3 antibodies
BioLegend
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ABEOMICS Inc.
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United States Biological
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Abbiotec
3 antibodies
RayBiotech, Inc.
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Active Motif
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MyBioSource
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GenWay
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Antibodies.com
3 antibodies
PeproTech Inc.
3 antibodies
Creative Diagnostics
12 antibodies
EMD Millipore
3 antibodies
Sigma-Aldrich
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Abbexa
7 antibodies
eBioscience, An Affymetrix Company
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Rockland Immunochemicals, Inc.
1 antibody
Sino Biological Inc.
1 antibody