TGIF1

gene product
HPE4, TGIF
The protein encoded by this gene is a member of the three-amino acid loop extension (TALE) superclass of atypical homeodomains. TALE homeobox proteins are highly conserved transcription regulators. This particular homeodomain binds to a previously characterized retinoid X receptor responsive element from the cellular retinol-binding protein II promoter. In addition to its role in inhibiting 9-cis-retinoic acid-dependent RXR alpha transcription activation of the retinoic acid responsive element, the protein is an active transcriptional co-repressor of SMAD2 and may participate in the transmission of nuclear signals during development and in the adult. Mutations in this gene are associated with holoprosencephaly type 4, which is a structural anomaly of the brain. Alternative splicing has been observed at this locus and multiple splice variants encoding distinct isoforms are described. [provided by RefSeq, Jul 2013]
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342 antibodies from 29 providers.

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AntibodyRefsTypeWBELICCIPIHCFC
LifeSpan BioSciences, Inc.
38 antibodies
Atlas Antibodies
1 antibody
Santa Cruz Biotechnology
1 antibody
Affinity Biosciences
1 antibody
antibodies-online
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OriGene
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Biorbyt
10 antibodies
Abnova Corporation
5 antibodies
R&D Systems
3 antibodies
Invitrogen Antibodies
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1 antibody
Aviva Systems Biology
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Abgent
5 antibodies
Acris Antibodies GmbH
4 antibodies
GeneTex
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RabMAbs
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ProSci
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1 antibody
Boster Biological Technology
1 antibody
MyBioSource
5 antibodies
Creative Diagnostics
5 antibodies
Abbkine Scientific Co.Ltd.
1 antibody
St John's Laboratory
1 antibody
United States Biological
22 antibodies
Abbexa
3 antibodies
Sigma-Aldrich
3 antibodies
GenWay
1 antibody