ERN1

gene product
IRE1, IRE1P
This gene encodes the transmembrane protein kinase inositol-requiring enzyme 1. The encoded protein contains two functional catalytic domains, a serine/threonine-protein kinase domain and an endoribonuclease domain. This protein functions as a sensor of unfolded proteins in the endoplasmic reticulum (ER) and triggers an intracellular signaling pathway termed the unfolded protein response (UPR). The UPR is an ER stress response that is conserved from yeast to mammals and activates genes involved in degrading misfolded proteins, regulating protein synthesis and activating molecular chaperones. This protein specifically mediates the splicing and activation of the stress response transcription factor X-box binding protein 1. [provided by RefSeq, Aug 2017]
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Abnova Corporation
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Arigo
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Enzo Life Sciences
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Boster Biological Technology
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Antibodies.com
1 antibody
NSJ Bioreagents
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Creative Biolabs
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Everest Biotech
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Aviva Systems Biology
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RayBiotech, Inc.
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Abbiotec
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Leading Biology
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RabMAbs
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Abbexa
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GenWay
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Sino Biological Inc.
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