RPSA

gene product
37LRP, LAMR1, LRP, p40, SA
Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes. They have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. Many of the effects of laminin are mediated through interactions with cell surface receptors. These receptors include members of the integrin family, as well as non-integrin laminin-binding proteins. This gene encodes a high-affinity, non-integrin family, laminin receptor 1. This receptor has been variously called 67 kD laminin receptor, 37 kD laminin receptor precursor (37LRP) and p40 ribosome-associated protein. The amino acid sequence of laminin receptor 1 is highly conserved through evolution, suggesting a key biological function. It has been observed that the level of the laminin receptor transcript is higher in colon carcinoma tissue and lung cancer cell line than their normal counterparts. Also, there is a correlation between the upregulation of this polypeptide in cancer cells and their invasive and metastatic phenotype. Multiple copies of this gene exist, however, most of them are pseudogenes thought to have arisen from retropositional events. Two alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
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AntibodyRefsTypeWBELICCIPIHCFC
Invitrogen Antibodies
6 antibodies
Novus Biologicals
5 antibodies
GeneTex
6 antibodies
NSJ Bioreagents
3 antibodies
antibodies-online
123 antibodies
Boster Biological Technology
2 antibodies
LifeSpan BioSciences, Inc.
59 antibodies
NovoPro Bioscience Inc.
7 antibodies
OriGene
6 antibodies
Enzo Life Sciences
2 antibodies
Proteintech Group
3 antibodies
Abgent
2 antibodies
ProSci
1 antibody
Biorbyt
27 antibodies
Acris Antibodies GmbH
3 antibodies
Aviva Systems Biology
1 antibody
Santa Cruz Biotechnology
1 antibody
Bioworld Technology, Inc
1 antibody
Bethyl Laboratories
2 antibodies
Affinity Biosciences
1 antibody
RabMAbs
4 antibodies
Creative Biolabs
30 antibodies
Abnova Corporation
6 antibodies
MyBioSource
6 antibodies
St John's Laboratory
2 antibodies
Creative Diagnostics
4 antibodies
Abbkine Scientific Co.Ltd.
1 antibody
United States Biological
13 antibodies
Abbexa
3 antibodies
EMD Millipore
1 antibody
Sigma-Aldrich
3 antibodies
GenWay
1 antibody