Tissue expression
Cell line expression
Protein structure
DKC1
Dyskerin pseudouridine synthase 1Cbf5, DKC, dyskerin, NAP57, NOLA4, XAP101
This gene functions in two distinct complexes. It plays an active role in telomerase stabilization and maintenance, as well as recognition of snoRNAs containing H/ACA sequences which provides stability during biogenesis and assembly into H/ACA small nucleolar RNA ribonucleoproteins (snoRNPs). This gene is highly conserved and widely expressed, and may play additional roles in nucleo-cytoplasmic shuttling, DNA damage response, and cell adhesion. Mutations have been associated with X-linked dyskeratosis congenita. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]
Top validated antibodies |
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GeneTex | GTX109000 | 3 references | Polyclonal |
WB
ICC
IP
IHC |
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antibodies-online | ABIN2840353 | 2 references | Polyclonal |
WB
ICC
IHC
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Atlas Antibodies | HPA000166 | 4 references | Polyclonal |
WB
IHC |
|
LSBio | LS-C331737 | Polyclonal |
WB
ICC
IHC
|
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Novus Biologicals | NBP1-85156 | 5 references | Polyclonal |
WB
IHC |
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Supportive data in Antibodypedia
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Recommended by provider