ELANE

gene product
ELA2, HLE, HNE, NE
Elastases form a subfamily of serine proteases that hydrolyze many proteins in addition to elastin. Humans have six elastase genes which encode structurally similar proteins. The encoded preproprotein is proteolytically processed to generate the active protease. Following activation, this protease hydrolyzes proteins within specialized neutrophil lysosomes, called azurophil granules, as well as proteins of the extracellular matrix. The enzyme may play a role in degenerative and inflammatory diseases through proteolysis of collagen-IV and elastin. This protein also degrades the outer membrane protein A (OmpA) of E. coli as well as the virulence factors of such bacteria as Shigella, Salmonella and Yersinia. Mutations in this gene are associated with cyclic neutropenia and severe congenital neutropenia (SCN). This gene is present in a gene cluster on chromosome 19. [provided by RefSeq, Jan 2016]
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659 antibodies from 37 providers.

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R&D Systems
19 antibodies
antibodies-online
189 antibodies
Novus Biologicals
102 antibodies
Cell Signaling Technology, Inc
6 antibodies
Boster Biological Technology
2 antibodies
GeneTex
6 antibodies
Biorbyt
31 antibodies
LifeSpan BioSciences, Inc.
89 antibodies
NSJ Bioreagents
3 antibodies
Atlas Antibodies
1 antibody
Santa Cruz Biotechnology
1 antibody
NovoPro Bioscience Inc.
3 antibodies
Abbkine Scientific Co.Ltd.
1 antibody
Creative Biolabs
39 antibodies
Acris Antibodies GmbH
8 antibodies
Abnova Corporation
20 antibodies
Creative Diagnostics
10 antibodies
Arigo
3 antibodies
OriGene
5 antibodies
Abgent
4 antibodies
MyBioSource
6 antibodies
Aviva Systems Biology
2 antibodies
EMD Millipore
2 antibodies
RabMAbs
1 antibody
Invitrogen Antibodies
7 antibodies
St John's Laboratory
2 antibodies
ProSci
2 antibodies
Affinity Biosciences
1 antibody
Abbexa
3 antibodies
United States Biological
59 antibodies
GenWay
11 antibodies
RayBiotech, Inc.
3 antibodies
Enzo Life Sciences
1 antibody
Molecular Innovations
1 antibody
Sino Biological Inc.
2 antibodies
Sigma-Aldrich
2 antibodies