ELANE

gene product
ELA2, HLE, HNE, NE
Elastases form a subfamily of serine proteases that hydrolyze many proteins in addition to elastin. Humans have six elastase genes which encode the structurally similar proteins. The product of this gene hydrolyzes proteins within specialized neutrophil lysosomes, called azurophil granules, as well as proteins of the extracellular matrix following the protein's release from activated neutrophils. The enzyme may play a role in degenerative and inflammatory diseases by its proteolysis of collagen-IV and elastin of the extracellular matrix. This protein degrades the outer membrane protein A (OmpA) of E. coli as well as the virulence factors of such bacteria as Shigella, Salmonella and Yersinia. Mutations in this gene are associated with cyclic neutropenia and severe congenital neutropenia (SCN). This gene is clustered with other serine protease gene family members, azurocidin 1 and proteinase 3 genes, at chromosome 19pter. All 3 genes are expressed coordinately and their protein products are packaged together into azurophil granules during neutrophil differentiation. [provided by RefSeq, May 2009]
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560 antibodies from 35 providers.

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AntibodyRefsTypeWBELICCIPIHCFC
antibodies-online
189 antibodies
Novus Biologicals
73 antibodies
R&D Systems
10 antibodies
Boster Biological Technology
2 antibodies
Cell Signaling Technology, Inc
2 antibodies
GeneTex
5 antibodies
Biorbyt
24 antibodies
LifeSpan BioSciences, Inc.
85 antibodies
NSJ Bioreagents
2 antibodies
Atlas Antibodies
1 antibody
Santa Cruz Biotechnology
1 antibody
NovoPro Bioscience Inc.
3 antibodies
Abbkine Scientific Co.Ltd.
1 antibody
Acris Antibodies GmbH
8 antibodies
Invitrogen Antibodies
7 antibodies
Abnova Corporation
20 antibodies
Arigo
3 antibodies
OriGene
5 antibodies
Abgent
4 antibodies
MyBioSource
6 antibodies
Aviva Systems Biology
2 antibodies
EMD Millipore
2 antibodies
RabMAbs
1 antibody
Creative Diagnostics
6 antibodies
St John's Laboratory
2 antibodies
ProSci
2 antibodies
Abbexa
3 antibodies
United States Biological
59 antibodies
GenWay
11 antibodies
RayBiotech, Inc.
3 antibodies
Enzo Life Sciences
1 antibody
Molecular Innovations
1 antibody
Sino Biological Inc.
2 antibodies
Sigma-Aldrich
2 antibodies