CR1

gene product
CD35, KN
This gene is a member of the receptors of complement activation (RCA) family and is located in the 'cluster RCA' region of chromosome 1. The gene encodes a monomeric single-pass type I membrane glycoprotein found on erythrocytes, leukocytes, glomerular podocytes, and splenic follicular dendritic cells. The Knops blood group system is a system of antigens located on this protein. The protein mediates cellular binding to particles and immune complexes that have activated complement. Decreases in expression of this protein and/or mutations in its gene have been associated with gallbladder carcinomas, mesangiocapillary glomerulonephritis, systemic lupus erythematosus and sarcoidosis. Mutations in this gene have also been associated with a reduction in Plasmodium falciparum rosetting, conferring protection against severe malaria. Alternate allele-specific splice variants, encoding different isoforms, have been characterized. Additional allele specific isoforms, including a secreted form, have been described but have not been fully characterized. [provided by RefSeq, Jul 2008]
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Antibodies

 

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Antibodypedia Validation Initiative

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Conjugate

  or   Clear
Enhanced validation
Supportive data in Antibodypedia
Data presented on provider website
Data in Antibodypedia (inconclusive)
Recommended by provider
Validated within AVI
Eligible for validation within AVI
1040 antibodies from 39 providers.

Antibody properties

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AntibodyRefsTypeWBELICCIPIHCFC
Novus Biologicals
134 antibodies
NSJ Bioreagents
3 antibodies
NovoPro Bioscience Inc.
3 antibodies
Abgent
3 antibodies
Invitrogen Antibodies
20 antibodies
GeneTex
14 antibodies
Antibodies.com
3 antibodies
antibodies-online
429 antibodies
Aviva Systems Biology
9 antibodies
Biorbyt
50 antibodies
Acris Antibodies GmbH
26 antibodies
Atlas Antibodies
3 antibodies
Arigo
7 antibodies
Abnova Corporation
9 antibodies
Santa Cruz Biotechnology
1 antibody
LifeSpan BioSciences, Inc.
144 antibodies